PMID- 27166424
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20220408
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 92
IP  - 1089
DP  - 2016 Jul
TI  - Gout and diabetes: a common combination.
PG  - 372-8
LID - 10.1136/postgradmedj-2015-133691 [doi]
AB  - The aims of this cross-sectional study were to compare metabolic parameters in 
      people with gout and diabetes with gout only and type 2 diabetes mellitus (T2DM) 
      only. Fifty General Practices in NHS Ayrshire and Arran (population 340 377) 
      contributed data. The sample was split into three groups, those with both gout 
      and T2DM, those with gout only and those with T2DM only. The prevalence of gout 
      in Ayrshire and Arran was 2.65%. The prevalence of gout in people with type 1 and 
      2 diabetes was 1.90% (p=0.30) and 10.12% (p<10(-5)), respectively. Patients with 
      both conditions were significantly more likely to be male (p<10(-5)), older 
      (p<10(-5)), have a higher mean body mass index (p<0.001), higher triglycerides 
      (p<10(-4)), lower mean total, high-density lipoprotein- and low-density 
      lipoprotein cholesterol (p<10(-5)), lower estimated glomerular filtration rate 
      (p<0.001), neuropathy (p=0.02), lower haemoglobin (p<0.001), to be prescribed 
      more medications (p<10(-5)) and less likely to smoke (p<0.01). There was an 
      association between lower haemoglobin A1c and increased prevalence of gout 
      (p<0.001). 42.4% of patients with gout alone and 36.2% of those with both gout 
      and diabetes had a urate measure. This study defines much more clearly the 
      association between gout and T2DM. Of interest, in terms of lifestyle, both 
      better glycaemic control and smoking are associated with a higher prevalence of 
      gout.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/
FAU - Collier, Andrew
AU  - Collier A
AD  - Diabetes Day Centre, Ayr Hospital, Ayr, UK.
FAU - Stirling, Angus
AU  - Stirling A
AD  - Diabetes Day Centre, Ayr Hospital, Ayr, UK.
FAU - Cameron, Lyall
AU  - Cameron L
AD  - Department of Primary Care Quality and Development, NHS Ayrshire and Arran, Ailsa 
      Hospital, Ayr, UK.
FAU - Hair, Mario
AU  - Hair M
AD  - NHS Ayrshire and Arran, University Hospital Ayr, Ayr, UK.
FAU - Crosbie, David
AU  - Crosbie D
AD  - Department of Rheumatology, Southern General Hospital, Glasgow, UK.
LA  - eng
PT  - Journal Article
DEP - 20160510
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Body Mass Index
MH  - Cholesterol, LDL/blood
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 1/complications/diagnosis/epidemiology/metabolism
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology/metabolism
MH  - Diabetic Neuropathies/epidemiology
MH  - Female
MH  - *Gout/complications/diagnosis/epidemiology/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Sex Factors
MH  - Statistics as Topic
MH  - Triglycerides/blood
MH  - United Kingdom/epidemiology
EDAT- 2016/05/12 06:00
MHDA- 2017/03/10 06:00
CRDT- 2016/05/12 06:00
PHST- 2015/08/28 00:00 [received]
PHST- 2015/12/14 00:00 [accepted]
PHST- 2016/05/12 06:00 [entrez]
PHST- 2016/05/12 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
AID - postgradmedj-2015-133691 [pii]
AID - 10.1136/postgradmedj-2015-133691 [doi]
PST - ppublish
SO  - Postgrad Med J. 2016 Jul;92(1089):372-8. doi: 10.1136/postgradmedj-2015-133691. 
      Epub 2016 May 10.