PMID- 27167448
OWN - NLM
STAT- MEDLINE
DCOM- 20170904
LR  - 20221207
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 219
IP  - 4-5
DP  - 2016 Jul
TI  - Prenatal triclosan exposure and cord blood immune system biomarkers.
PG  - 454-7
LID - S1438-4639(16)30033-5 [pii]
LID - 10.1016/j.ijheh.2016.04.010 [doi]
AB  - Triclosan is widely used as an antimicrobial agent and preservative that has been 
      hypothesized to play a role in asthma and allergic disease. The limited body of 
      literature regarding the allergenicity of triclosan has not evaluated prenatal 
      exposure and subsequent potential effects on the developing immune system. The 
      objective of the present study was to determine the association between prenatal 
      urinary triclosan concentrations and cord blood immune system biomarker 
      concentrations. Umbilical cord blood samples were obtained from the 
      Maternal-Infant Research on Environmental Chemicals (MIREC) Biobank and were 
      tested for three immune system biomarkers: immunoglobulin E (IgE), thymic stromal 
      lymphopoietin (TSLP), and interleukin-33 (IL-33). Triclosan concentrations were 
      measured in urine at 6-13 weeks gestation. No statistically significant 
      associations were observed between prenatal triclosan concentrations and elevated 
      concentrations of any immune system biomarker (n=1219 participants). Longitudinal 
      studies are necessary to determine how the observed findings at birth translate 
      into childhood.
CI  - Copyright (c) 2016 The Authors. Published by Elsevier GmbH.. All rights reserved.
FAU - Ashley-Martin, Jillian
AU  - Ashley-Martin J
AD  - Perinatal Epidemiology Research Unit, Departments of Obstetrics & Gynecology and 
      Pediatrics, Dalhousie University, Halifax, NS B3K 6R8, Canada. Electronic 
      address: jillian.ashley-martin@dal.ca.
FAU - Dodds, Linda
AU  - Dodds L
AD  - Perinatal Epidemiology Research Unit, Departments of Obstetrics & Gynecology and 
      Pediatrics, Dalhousie University, Halifax, NS B3K 6R8, Canada. Electronic 
      address: l.dodds@dal.ca.
FAU - Arbuckle, Tye E
AU  - Arbuckle TE
AD  - Population Studies Division, Healthy Environments and Consumer Safety Branch, 
      Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: 
      tye.arbuckle@hc-sc.gc.ca.
FAU - Marshall, Jean
AU  - Marshall J
AD  - Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 
      4R2, Canada. Electronic address: jean.marshall@dal.ca.
LA  - eng
GR  - MOP-81285/CIHR/Canada
PT  - Journal Article
DEP - 20160427
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Environmental Pollutants)
RN  - 0 (IL33 protein, human)
RN  - 0 (Interleukin-33)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4NM5039Y5X (Triclosan)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Adult
MH  - Anti-Infective Agents, Local/*urine
MH  - Biomarkers/blood
MH  - Cytokines/blood
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*urine
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-33/blood
MH  - *Maternal Exposure
MH  - Odds Ratio
MH  - Pregnancy
MH  - Triclosan/*urine
MH  - Thymic Stromal Lymphopoietin
OTO - NOTNLM
OT  - Birth cohort
OT  - Immune system development
OT  - Pregnancy
OT  - Triclosan
EDAT- 2016/05/12 06:00
MHDA- 2017/09/05 06:00
CRDT- 2016/05/12 06:00
PHST- 2016/03/09 00:00 [received]
PHST- 2016/04/22 00:00 [revised]
PHST- 2016/04/23 00:00 [accepted]
PHST- 2016/05/12 06:00 [entrez]
PHST- 2016/05/12 06:00 [pubmed]
PHST- 2017/09/05 06:00 [medline]
AID - S1438-4639(16)30033-5 [pii]
AID - 10.1016/j.ijheh.2016.04.010 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2016 Jul;219(4-5):454-7. doi: 
      10.1016/j.ijheh.2016.04.010. Epub 2016 Apr 27.