PMID- 27167681
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20161231
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 35
IP  - 6
DP  - 2016 Jun
TI  - Epilepsy, Seizures, and Inflammation: Role of the C-C Motif Ligand 2 Chemokine.
PG  - 257-60
LID - 10.1089/dna.2016.3345 [doi]
AB  - Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. 
      Several lines of evidence demonstrate that inflammatory processes within the 
      brain parenchyma contribute to recurrence and precipitation of seizures. In both 
      epileptic patients and animal models, seizures upregulate inflammatory mediators, 
      which in turn may enhance brain excitability. We recently showed that the C-C 
      motif ligand 2 (CCL2) chemokine (also known as monocyte chemoattractant protein-1 
      [MCP-1]) mediates the seizure-promoting effects of inflammation. Systemic 
      inflammatory challenge in chronically epileptic mice markedly enhanced seizure 
      frequency and upregulated CCL2 expression in the brain. Selective pharmacological 
      blockade of CCL2 synthesis or C-C chemokine receptor type 2 (CCR2) significantly 
      suppressed inflammation-induced seizures. These results have important 
      implications for the development of novel anticonvulsant therapies: drugs 
      interfering with CCL2 signaling are used clinically for several human disorders 
      and might be redirected for use in pharmacoresistant epilepsy. Here we review the 
      role of CCL2/CCR2 signaling in linking systemic inflammation with seizure 
      susceptibility and discuss some open questions that arise from our recent 
      studies.
FAU - Bozzi, Yuri
AU  - Bozzi Y
AD  - 1 Centre for Integrative Biology (CIBIO), University of Trento , Trento, Italy .
AD  - 2 Neuroscience Institute , National Research Council (CNR), Pisa, Italy .
FAU - Caleo, Matteo
AU  - Caleo M
AD  - 2 Neuroscience Institute , National Research Council (CNR), Pisa, Italy .
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160511
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*metabolism
MH  - Disease Susceptibility
MH  - Encephalitis/*pathology
MH  - Epilepsy/*pathology
MH  - Mice
MH  - Receptors, CCR2/metabolism
MH  - Seizures
MH  - *Signal Transduction
EDAT- 2016/05/12 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/05/12 06:00
PHST- 2016/05/12 06:00 [entrez]
PHST- 2016/05/12 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.1089/dna.2016.3345 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2016 Jun;35(6):257-60. doi: 10.1089/dna.2016.3345. Epub 2016 May 
      11.