PMID- 27168952
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160512
LR  - 20200930
IS  - 2164-7712 (Print)
IS  - 2164-7712 (Electronic)
VI  - 5
IP  - 1
DP  - 2016
TI  - Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients 
      with primary selective IgM deficiency.
PG  - 21-32
AB  - Primary selective IgM deficiency (SIGMD) is a rare and recently IUIS-recognized 
      primary immunodeficiency disease with increased susceptibility to infections, 
      allergy, and autoimmune diseases. The pathogenesis of selective IgM remains 
      unclear. The objective of the study was to understand the pathogenesis of 
      selective IgM deficiency via a comprehensive analysis of subsets of B cells, 
      naive and memory subsets of CD4+ and CD8+ T cells, and Breg, CD4Treg, and CD8Treg 
      cells. Twenty adult patients with SIGMD (serum IgM 4 mg/dl-32 mg/dl) and age-and 
      gender-matched healthy controls were studied. Naive B cells, transitional B 
      cells, marginal zone B cells, germinal center B cells, IgM memory B cells, 
      switched memory B cells, plasmablasts, CD21(low) B cells, B1 cells, CXCR3+ naive 
      and memory B cells; naive, central memory, and effector memory subsets of CD4+ 
      and CD8+ T cells, and CD4Treg, CD8Treg and Breg were phenotypically analyzed 
      using multicolor flow cytometry. A significant increase in CD21(low), IgM memory 
      B cells, Breg and CD8Treg, and a significant decreased in germinal center B 
      cells, and CXCR3+ naive and memory B cells were observed in SIGMD. These 
      alterations in subsets of B cells, and Breg and CD8Treg cells may play a role in 
      the pathogenesis of SIGMD.
FAU - Louis, Ankmalika Gupta
AU  - Louis AG
AD  - Program in Primary Immunodeficiency and Human Aging, Division of Basic and 
      Clinical Immunology, University of California Irvine, California, USA.
FAU - Agrawal, Sudhanshu
AU  - Agrawal S
AD  - Program in Primary Immunodeficiency and Human Aging, Division of Basic and 
      Clinical Immunology, University of California Irvine, California, USA.
FAU - Gupta, Sudhir
AU  - Gupta S
AD  - Program in Primary Immunodeficiency and Human Aging, Division of Basic and 
      Clinical Immunology, University of California Irvine, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20160323
PL  - United States
TA  - Am J Clin Exp Immunol
JT  - American journal of clinical and experimental immunology
JID - 101587157
PMC - PMC4858603
OTO - NOTNLM
OT  - B1 cells
OT  - Breg
OT  - CD21lo
OT  - CD4Treg
OT  - CD8Treg
OT  - CXCR3+ B cells
OT  - germinal center B cells
OT  - marginal zone B cells
OT  - memory B cells
OT  - memory T cells
OT  - transitional B cells
EDAT- 2016/05/12 06:00
MHDA- 2016/05/12 06:01
PMCR- 2016/03/23
CRDT- 2016/05/12 06:00
PHST- 2016/01/11 00:00 [received]
PHST- 2016/03/04 00:00 [accepted]
PHST- 2016/05/12 06:00 [entrez]
PHST- 2016/05/12 06:00 [pubmed]
PHST- 2016/05/12 06:01 [medline]
PHST- 2016/03/23 00:00 [pmc-release]
PST - epublish
SO  - Am J Clin Exp Immunol. 2016 Mar 23;5(1):21-32. eCollection 2016.