PMID- 27169601
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20220815
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Print)
IS  - 1058-0468 (Linking)
VI  - 33
IP  - 7
DP  - 2016 Jul
TI  - Immunogenetic contributions to recurrent pregnancy loss.
PG  - 833-47
LID - 10.1007/s10815-016-0720-6 [doi]
AB  - While sporadic pregnancy loss is common, occurring in 15 % of pregnancies, 
      recurrent pregnancy loss (RPL) impacts approximately 5 % of couples. Though 
      multiple causes are known (including structural, hormonal, infectious, 
      autoimmune, and thrombophilic causes), after evaluation, roughly half of all 
      cases remain unexplained. The idiopathic RPL cases pose a challenging therapeutic 
      dilemma in addition to incurring much physical and emotional morbidity. 
      Immunogenetic causes have been postulated to contribute to these cases of RPL. 
      Natural Killer cell, T cell expression pattern changes in the endometrium have 
      both been shown in patients with RPL. Human leukocyte antigen (HLA) and cytokine 
      allelic variations have also been studied as etiologies for RPL. Some of the 
      results have been promising, however the studies are small and have not yet put 
      forth outcomes that would change our current diagnosis and management of RPL. 
      Larger database studies are needed with stricter control criteria before 
      reasonable conclusions can be drawn.
FAU - Grimstad, Frances
AU  - Grimstad F
AD  - Department of Obstetrics and Gynecology, University of Kansas, 3901 Rainbow Blvd 
      MS 2028, Kansas City, KS, 66160, USA. fgrimstad@kumc.edu.
FAU - Krieg, Sacha
AU  - Krieg S
AD  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics 
      and Gynecology, Oregon Health Sciences University, Portland, OR, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160512
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Abortion, Habitual/*genetics/*immunology/pathology
MH  - Cytokines/immunology
MH  - Endometrium/*cytology/immunology
MH  - Female
MH  - HLA Antigens/genetics/*immunology
MH  - Humans
MH  - Immunogenetics
MH  - Killer Cells, Natural/*immunology
MH  - Ovary/pathology
MH  - T-Lymphocytes/*immunology
MH  - Uterus/pathology
PMC - PMC4930783
OTO - NOTNLM
OT  - HY-Antibodies
OT  - Human leukocyte antigens
OT  - Immunogenetics
OT  - Recurrent pregnancy loss
OT  - T regulatory cell
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2016/05/14 06:00
MHDA- 2017/03/14 06:00
PMCR- 2017/07/01
CRDT- 2016/05/13 06:00
PHST- 2016/03/02 00:00 [received]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/13 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - 10.1007/s10815-016-0720-6 [pii]
AID - 720 [pii]
AID - 10.1007/s10815-016-0720-6 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2016 Jul;33(7):833-47. doi: 10.1007/s10815-016-0720-6. 
      Epub 2016 May 12.