PMID- 27170338 OWN - NLM STAT- MEDLINE DCOM- 20181011 LR - 20240130 IS - 1532-6551 (Electronic) IS - 1071-3581 (Linking) VI - 24 IP - 5 DP - 2017 Oct TI - Feasibility of data-driven cardiac respiratory motion correction of myocardial perfusion CZT SPECT: A pilot study. PG - 1598-1607 LID - 10.1007/s12350-016-0493-4 [doi] AB - BACKGROUND: We developed a data-driven respiratory motion (RM) correction method (REGAT program) for multiple-pinhole detector CZT SPECT. We verified its clinical feasibility with myocardial perfusion imaging (MPI) and studied its impact on image characteristics. METHODS: This retrospective study included 18 patients having stress/rest (99m)Tc-Tetrofosmin MPI SPECT. List mode was acquired on CZT SPECT and processed with REGAT. REGAT generates reconstructed RM-gated volumes that are summed either without realignment (NR-SPECT) or after realignment (R-SPECT). For both stress and rest, we calculated the maximal RM in the 3 axis, and image characteristics of both R-SPECT and NR-SPECT: minimum left ventricular (LV) cavity counts (LV-Min), maximum LV myocardial counts (LV-Max), LV contrast, and FWHM of both anterior (FWHM-ant) and inferior (FWHM-inf) LV myocardial walls. RESULTS: At both stress and rest, cranio-caudal motion was the dominant axial movement and REGAT had a positive impact on image characteristics as reflected by variations between R-SPECT and NR-SPECT in LV-Min, LV-Max, FWHM-ant, FWHM-inf, and contrast. These latter were well correlated to the amplitude of cranio-caudal motion at both stress and rest. CONCLUSIONS: Data-driven RM correction of MPI acquired with CZT SPECT is clinically feasible and easily applicable. It presents interesting impact on image characteristics. FAU - Daou, Doumit AU - Daou D AD - EA 7334 REMES, Universite Paris-Diderot, Sorbonne Paris-Cite, Paris, France. doumit.daou@cch.aphp.fr. AD - Nuclear Medicine Department, Cochin University Hospital, AP-HP, 27 rue du Faubourg Saint-Jacques, 75679, Paris Cedex 14, France. doumit.daou@cch.aphp.fr. FAU - Sabbah, Remy AU - Sabbah R AD - Nuclear Medicine Department, CHU Jean Minjoz, Besancon, France. FAU - Coaguila, Carlos AU - Coaguila C AD - Nuclear Medicine Department, Centre Hospitalier de Bigorre, Tarbes, France. FAU - Boulahdour, Hatem AU - Boulahdour H AD - Nuclear Medicine Department, CHU Jean Minjoz, Besancon, France. LA - eng PT - Journal Article DEP - 20160511 PL - United States TA - J Nucl Cardiol JT - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology JID - 9423534 RN - 0 (Organophosphorus Compounds) RN - 0 (Organotechnetium Compounds) RN - 42FOP1YX93 (technetium tc-99m tetrofosmin) SB - IM CIN - J Nucl Cardiol. 2017 Oct;24(5):1608-1609. PMID: 27194009 MH - Aged MH - *Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography MH - Feasibility Studies MH - Female MH - Heart/diagnostic imaging MH - Heart Ventricles/diagnostic imaging MH - Humans MH - Image Processing, Computer-Assisted MH - Linear Models MH - Male MH - Middle Aged MH - Motion MH - *Myocardial Perfusion Imaging MH - Organophosphorus Compounds MH - Organotechnetium Compounds MH - Pilot Projects MH - *Respiration MH - Retrospective Studies MH - Software MH - *Tomography, Emission-Computed, Single-Photon OTO - NOTNLM OT - CZT OT - gated SPECT OT - myocardial perfusion imaging OT - respiratory gating OT - respiratory motion EDAT- 2016/05/14 06:00 MHDA- 2018/10/12 06:00 CRDT- 2016/05/13 06:00 PHST- 2016/02/19 00:00 [received] PHST- 2016/03/29 00:00 [accepted] PHST- 2016/05/14 06:00 [pubmed] PHST- 2018/10/12 06:00 [medline] PHST- 2016/05/13 06:00 [entrez] AID - S1071-3581(23)06663-1 [pii] AID - 10.1007/s12350-016-0493-4 [doi] PST - ppublish SO - J Nucl Cardiol. 2017 Oct;24(5):1598-1607. doi: 10.1007/s12350-016-0493-4. Epub 2016 May 11.