PMID- 27170368
OWN - NLM
STAT- MEDLINE
DCOM- 20170802
LR  - 20181202
IS  - 1534-6293 (Electronic)
IS  - 1528-4042 (Linking)
VI  - 16
IP  - 7
DP  - 2016 Jul
TI  - Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis.
PG  - 61
LID - 10.1007/s11910-016-0668-z [doi]
AB  - Autoimmune myasthenia gravis (MG) is the prototypic, antibody-mediated 
      neuromuscular disease and is characterized by a decrease in the number of 
      functional acetylcholine receptors (AChR) within the muscle end plate zone of the 
      neuromuscular junction (NMJ). Although the pathophysiology of AChR-mediated 
      myasthenia gravis has been extensively studied over the last 40 years since its 
      original description by Patrick and Lindstrom (Science 180:871-872, 1973), less 
      is known about the much more recently described muscle-specific kinase (MuSK) 
      antibody-mediated MG. MuSK-MG has features clinically distinct from Ach-R MG, as 
      well as a different pattern of response to treatment and a unique 
      immunopathogenesis.
FAU - Hurst, Rebecca L
AU  - Hurst RL
AD  - Department of Neurology, University of South Florida Morsani College of Medicine, 
      2 Tampa General Circle 6th Floor, Room 6091, Tampa, FL, 33606, USA. 
      rlhurst@health.usf.edu.
FAU - Gooch, Clifton L
AU  - Gooch CL
AD  - Department of Neurology, University of South Florida Morsani College of Medicine, 
      2 Tampa General Circle 6th Floor, Room 6091, Tampa, FL, 33606, USA.
AD  - Department of Neurology, University of South Florida Morsani College of Medicine, 
      12901 Bruce B. Downs Blvd MDC 55, Tampa, FL, 33612, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Neurol Neurosci Rep
JT  - Current neurology and neuroscience reports
JID - 100931790
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Autoantibodies/*immunology
MH  - Humans
MH  - *Myasthenia Gravis/diagnosis/immunology/therapy
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
OTO - NOTNLM
OT  - Acetylcholine receptor antibody
OT  - Muscle-specific receptor tyrosine kinase
OT  - Myasthenia gravis
OT  - Neuromuscular junction
EDAT- 2016/05/14 06:00
MHDA- 2017/08/03 06:00
CRDT- 2016/05/13 06:00
PHST- 2016/05/13 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/08/03 06:00 [medline]
AID - 10.1007/s11910-016-0668-z [pii]
AID - 10.1007/s11910-016-0668-z [doi]
PST - ppublish
SO  - Curr Neurol Neurosci Rep. 2016 Jul;16(7):61. doi: 10.1007/s11910-016-0668-z.