PMID- 27171378
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20190423
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 5
DP  - 2016
TI  - Plasma Levels of Monocyte Chemoattractant Protein-1, n-Terminal Fragment of Brain 
      Natriuretic Peptide and Calcidiol Are Independently Associated with the 
      Complexity of Coronary Artery Disease.
PG  - e0152816
LID - 10.1371/journal.pone.0152816 [doi]
LID - e0152816
AB  - BACKGROUND AND OBJECTIVES: We investigated the relationship of the Syntax Score 
      (SS) and coronary artery calcification (CAC), with plasma levels of biomarkers 
      related to cardiovascular damage and mineral metabolism, as there is sparse 
      information in this field. METHODS: We studied 270 patients with coronary disease 
      that had an acute coronary syndrome (ACS) six months before. Calcidiol, 
      fibroblast growth factor-23, parathormone, phosphate and monocyte chemoattractant 
      protein-1 [MCP-1], high-sensitivity C-reactive protein, galectin-3, and 
      N-terminal pro-brain natriuretic peptide [NT-proBNP] levels, among other 
      biomarkers, were determined. CAC was assessed by coronary angiogram as low-grade 
      (0-1) and high-grade (2-3) calcification, measured with a semiquantitative scale 
      ranging from 0 (none) to 3 (severe). For the SS study patients were divided in 
      SS<14 and SS>/=14. Multivariate linear and logistic regression analyses were 
      performed. RESULTS: MCP-1 predicted independently the SS (RC = 1.73 [95%CI = 
      0.08-3.39]; p = 0.040), along with NT-proBNP (RC = 0.17 [95%CI = 0.05-0.28]; p = 
      0.004), male sex (RC = 4.15 [95%CI = 1.47-6.83]; p = 0.003), age (RC = 0.13 
      [95%CI = 0.02-0.24]; p = 0.020), hypertension (RC = 3.64, [95%CI = 0.77-6.50]; p 
      = 0.013), hyperlipidemia (RC = 2.78, [95%CI = 0.28-5.29]; p = 0.030), and statins 
      (RC = 6.12 [95%CI = 1.28-10.96]; p = 0.013). Low calcidiol predicted high-grade 
      calcification independently (OR = 0.57 [95% CI = 0.36-0.90]; p = 0.013) along 
      with ST-elevation myocardial infarction (OR = 0.38 [95%CI = 0.19-0.78]; p = 
      0.006), diabetes (OR = 2.35 [95%CI = 1.11-4.98]; p = 0.028) and age (OR = 1.37 
      [95%CI = 1.18-1.59]; p<0.001). During follow-up (1.79 [0.94-2.86] years), 27 
      patients developed ACS, stroke, or transient ischemic attack. A combined score 
      using SS and CAC predicted independently the development of the outcome. 
      CONCLUSIONS: MCP-1 and NT-proBNP are independent predictors of SS, while low 
      calcidiol plasma levels are associated with CAC. More studies are needed to 
      confirm these data.
FAU - Martin-Reyes, Roberto
AU  - Martin-Reyes R
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Franco-Pelaez, Juan Antonio
AU  - Franco-Pelaez JA
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Lorenzo, Oscar
AU  - Lorenzo O
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, Madrid, Spain.
AD  - Autonoma University, Madrid, Spain.
FAU - Gonzalez-Casaus, Maria Luisa
AU  - Gonzalez-Casaus ML
AD  - Laboratory of Nephrology and Mineral Metabolism, Hospital Gomez-Ulla, Madrid, 
      Spain.
FAU - Pello, Ana Maria
AU  - Pello AM
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Acena, Alvaro
AU  - Acena A
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Carda, Rocio
AU  - Carda R
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Martin-Ventura, Jose Luis
AU  - Martin-Ventura JL
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, Madrid, Spain.
AD  - Autonoma University, Madrid, Spain.
FAU - Blanco-Colio, Luis
AU  - Blanco-Colio L
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, Madrid, Spain.
FAU - Martin-Mariscal, Maria Luisa
AU  - Martin-Mariscal ML
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Martinez-Milla, Juan
AU  - Martinez-Milla J
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Villa-Bellosta, Ricardo
AU  - Villa-Bellosta R
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, Madrid, Spain.
FAU - Pinero, Antonio
AU  - Pinero A
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Navarro, Felipe
AU  - Navarro F
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
FAU - Egido, Jesus
AU  - Egido J
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, Madrid, Spain.
AD  - Autonoma University, Madrid, Spain.
AD  - Department of Nephrology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
AD  - CIBERDEM, Madrid, Spain.
FAU - Tunon, Jose
AU  - Tunon J
AD  - Department of Cardiology, Instituto de Investigacion Sanitaria-Fundacion Jimenez 
      Diaz, Madrid, Spain.
AD  - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion 
      Jimenez Diaz, Madrid, Spain.
AD  - Autonoma University, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160512
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Calcifediol/*blood
MH  - Calcinosis
MH  - Chemokine CCL2/*blood
MH  - Coronary Artery Disease/*blood/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Vascular Calcification/metabolism/pathology
PMC - PMC4865225
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/05/14 06:00
MHDA- 2017/04/07 06:00
PMCR- 2016/05/12
CRDT- 2016/05/13 06:00
PHST- 2015/12/21 00:00 [received]
PHST- 2016/03/18 00:00 [accepted]
PHST- 2016/05/13 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
PHST- 2016/05/12 00:00 [pmc-release]
AID - PONE-D-15-55148 [pii]
AID - 10.1371/journal.pone.0152816 [doi]
PST - epublish
SO  - PLoS One. 2016 May 12;11(5):e0152816. doi: 10.1371/journal.pone.0152816. 
      eCollection 2016.