PMID- 27172087
OWN - NLM
STAT- MEDLINE
DCOM- 20180214
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 16
IP  - 12
DP  - 2016 Dec
TI  - Anti-LG3 Antibodies Aggravate Renal Ischemia-Reperfusion Injury and Long-Term 
      Renal Allograft Dysfunction.
PG  - 3416-3429
LID - 10.1111/ajt.13866 [doi]
AB  - Pretransplant autoantibodies to LG3 and angiotensin II type 1 receptors (AT1R) 
      are associated with acute rejection in kidney transplant recipients, whereas 
      antivimentin autoantibodies participate in heart transplant rejection. 
      Ischemia-reperfusion injury (IRI) can modify self-antigenic targets. We 
      hypothesized that ischemia-reperfusion creates permissive conditions for 
      autoantibodies to interact with their antigenic targets and leads to enhanced 
      renal damage and dysfunction. In 172 kidney transplant recipients, we found that 
      pretransplant anti-LG3 antibodies were associated with an increased risk of 
      delayed graft function (DGF). Pretransplant anti-LG3 antibodies are inversely 
      associated with graft function at 1 year after transplantation in patients who 
      experienced DGF, independent of rejection. Pretransplant anti-AT1R and 
      antivimentin were not associated with DGF or its functional outcome. In a model 
      of renal IRI in mice, passive transfer of anti-LG3 IgG led to enhanced 
      dysfunction and microvascular injury compared with passive transfer with control 
      IgG. Passive transfer of anti-LG3 antibodies also favored intrarenal 
      microvascular complement activation, microvascular rarefaction and fibrosis after 
      IRI. Our results suggest that anti-LG3 antibodies are novel aggravating factors 
      for renal IRI. These results provide novel insights into the pathways that 
      modulate the severity of renal injury at the time of transplantation and their 
      impact on long-term outcomes.
CI  - (c) Copyright 2016 The American Society of Transplantation and the American Society 
      of Transplant Surgeons.
FAU - Yang, B
AU  - Yang B
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Dieude, M
AU  - Dieude M
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Hamelin, K
AU  - Hamelin K
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Henault-Rondeau, M
AU  - Henault-Rondeau M
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Patey, N
AU  - Patey N
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
AD  - Department of Pathology, CHU Ste-Justine, Universite de Montreal, Montreal, QC, 
      Canada.
FAU - Turgeon, J
AU  - Turgeon J
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Lan, S
AU  - Lan S
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Pomerleau, L
AU  - Pomerleau L
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
FAU - Quesnel, M
AU  - Quesnel M
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
FAU - Peng, J
AU  - Peng J
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
FAU - Tremblay, J
AU  - Tremblay J
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
FAU - Shi, Y
AU  - Shi Y
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Chan, J S
AU  - Chan JS
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Hebert, M J
AU  - Hebert MJ
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
FAU - Cardinal, H
AU  - Cardinal H
AD  - Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), 
      Montreal, QC, Canada.
AD  - Canadian National Transplant Research Program, Edmonton, Alberta, T6G 2E1, 
      Canada.
AD  - Universite de Montreal, Montreal, QC, Canada.
LA  - eng
GR  - MOP-15447/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160623
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Autoantibodies)
RN  - 0 (Heparan Sulfate Proteoglycans)
RN  - 143972-95-6 (perlecan)
SB  - IM
MH  - Animals
MH  - Autoantibodies/*blood/immunology
MH  - Delayed Graft Function/blood/*etiology/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Graft Survival/*immunology
MH  - Heparan Sulfate Proteoglycans/*immunology
MH  - Humans
MH  - Kidney Failure, Chronic/surgery
MH  - Kidney Function Tests
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Middle Aged
MH  - Prognosis
MH  - Reperfusion Injury/blood/*etiology/pathology
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - autoimmunity
OT  - basic (laboratory) research/science
OT  - clinical research/practice
OT  - complement biology
OT  - delayed graft function (DGF)
OT  - immunobiology
OT  - ischemia reperfusion injury (IRI)
OT  - kidney (allograft) function/dysfunction
OT  - kidney transplantation/nephrology
EDAT- 2016/05/14 06:00
MHDA- 2018/02/15 06:00
CRDT- 2016/05/13 06:00
PHST- 2015/09/30 00:00 [received]
PHST- 2016/05/04 00:00 [revised]
PHST- 2016/05/07 00:00 [accepted]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2018/02/15 06:00 [medline]
PHST- 2016/05/13 06:00 [entrez]
AID - S1600-6135(22)00685-2 [pii]
AID - 10.1111/ajt.13866 [doi]
PST - ppublish
SO  - Am J Transplant. 2016 Dec;16(12):3416-3429. doi: 10.1111/ajt.13866. Epub 2016 Jun 
      23.