PMID- 27172251
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20220330
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Print)
IS  - 0007-0920 (Linking)
VI  - 115
IP  - 1
DP  - 2016 Jun 28
TI  - Dietary total antioxidant capacity and pancreatic cancer risk: an Italian 
      case-control study.
PG  - 102-7
LID - 10.1038/bjc.2016.114 [doi]
AB  - BACKGROUND: Pancreatic cancer is one of the leading causes of cancer mortality. 
      Diet may be associated with pancreatic cancer, but it is unknown whether specific 
      dietary components contribute to its risk. The potential differential role of 
      dietary antioxidants warrants further investigation. METHODS: We analysed data 
      from a case-control study of 326 pancreatic cancer cases and 652 controls 
      conducted between 1991 and 2008 in Northern Italy. Subjects' usual diet was 
      assessed through a validated and reproducible food frequency questionnaire. Using 
      this information and an Italian food composition database, we calculated three 
      indices of dietary total antioxidant capacity (TAC): Trolox equivalent 
      antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP) 
      and ferric-reducing antioxidant power (FRAP). We estimated the odds ratios (ORs) 
      and 95% confidence intervals (CIs) for pancreatic cancer using multiple logistic 
      regression models conditioned on study centre, sex and age, and adjusted for 
      major known pancreatic cancer risk factors. RESULTS: Significant inverse 
      associations were found for the highest tertile of TAC compared with the lowest 
      tertile for both TEAC and FRAP. The ORs were 0.61 (95% CI 0.39-0.94, P-value for 
      trend 0.03) and 0.63 (95% CI 0.41-0.99, P-value for trend 0.05), respectively. 
      Total radical-trapping antioxidant parameter was inversely, but not 
      significantly, associated with pancreatic cancer risk, with an OR of 0.78 (95% CI 
      0.49-1.24, P-value for trend 0.27). CONCLUSIONS: Diet high in TAC, as measured by 
      TEAC and FRAP, is inversely associated with pancreatic cancer risk.
FAU - Lucas, Aimee L
AU  - Lucas AL
AD  - Samuel Bronfman Department of Medicine, Henry D. Janowitz Division of 
      Gastroenterology, Icahn School of Medicine at Mount Sinai, New York 10029, USA.
FAU - Bosetti, Cristina
AU  - Bosetti C
AD  - Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche 'Mario 
      Negri', Milan 20156, Italy.
FAU - Boffetta, Paolo
AU  - Boffetta P
AD  - Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York 10029, 
      USA.
FAU - Negri, Eva
AU  - Negri E
AD  - Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche 'Mario 
      Negri', Milan 20156, Italy.
FAU - Tavani, Alessandra
AU  - Tavani A
AD  - Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche 'Mario 
      Negri', Milan 20156, Italy.
FAU - Serafini, Mauro
AU  - Serafini M
AD  - Functional Foods and Metabolic Stress Prevention Laboratory, Center for Food and 
      Nutrition, Research Center on Agriculture and Economics, Rome 00178, Italy.
FAU - Polesel, Jerry
AU  - Polesel J
AD  - Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, 
      Aviano (PN) 33081, Italy.
FAU - Serraino, Diego
AU  - Serraino D
AD  - Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, 
      Aviano (PN) 33081, Italy.
FAU - La Vecchia, Carlo
AU  - La Vecchia C
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan 20133, Italy.
FAU - Rossi, Marta
AU  - Rossi M
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan 20133, Italy.
LA  - eng
GR  - KL2 TR000069/TR/NCATS NIH HHS/United States
GR  - KL2 TR001435/TR/NCATS NIH HHS/United States
GR  - UL1 TR000067/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160512
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Antioxidants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*metabolism
MH  - Case-Control Studies
MH  - Diet/methods
MH  - Feeding Behavior/physiology
MH  - Female
MH  - Humans
MH  - Italy
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pancreatic Neoplasms/*etiology/metabolism
MH  - Risk Factors
PMC - PMC4931362
EDAT- 2016/05/14 06:00
MHDA- 2017/06/07 06:00
PMCR- 2017/06/28
CRDT- 2016/05/13 06:00
PHST- 2015/12/30 00:00 [received]
PHST- 2016/03/18 00:00 [revised]
PHST- 2016/04/05 00:00 [accepted]
PHST- 2016/05/13 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
PHST- 2017/06/28 00:00 [pmc-release]
AID - bjc2016114 [pii]
AID - 10.1038/bjc.2016.114 [doi]
PST - ppublish
SO  - Br J Cancer. 2016 Jun 28;115(1):102-7. doi: 10.1038/bjc.2016.114. Epub 2016 May 
      12.