PMID- 27173183
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 15
IP  - 2
DP  - 2016 Apr 4
TI  - Gender and ethnicity modify the association between the CYP1A2 rs762551 
      polymorphism and habitual coffee intake: evidence from a meta-analysis.
LID - 10.4238/gmr.15027487 [doi]
AB  - The association between the single nucleotide polymorphism rs762551 in the 
      cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption 
      remains controversial. We conducted a meta-analysis to clarify this potential 
      association. Twelve studies were selected from articles retrieved from the and 
      Google Scholar databases, and the data were analyzed to determine the odds ratio 
      (OR) of genotypes AA (conferring fast caffeine metabolism) vs AC + CC (conferring 
      slow caffeine metabolism). Comparisons were made between 6161 high caffeine 
      consumers and 3219 low caffeine consumers. The overall analysis showed a 
      significant association between genotype AA and coffee intake  [OR = 1.13, 95% 
      confidence interval (CI) = 1.03-1.24; Q = 19.23, P = 0.06; I2 = 43%]. In subgroup 
      analyses, the association was also found within male, younger, and Caucasian 
      subjects (OR = 1.21, 95%CI = 1.08- 1.35; OR = 1.71, 95%CI = 1.18-2.48; OR = 1.29, 
      95%CI = 1.12-1.49, respectively) but not in female, older, and Asian subjects (OR 
      = 0.98, 95%CI = 0.83-1.15; OR = 0.83, 95%CI = 0.56-1.22; OR = 0.91, 95%CI = 
      0.71-1.17, respectively). Therefore, the rs762551 AA genotype may lead to higher 
      coffee intake, especially in males, younger age groups, and individuals of 
      Caucasian ethnicity. Our data highlight the need to test other CYP1A2 
      polymorphisms showing significance in genome-wide association studies to clarify 
      the association with caffeine intake in the Asian population.
FAU - Denden, S
AU  - Denden S
AD  - Research Unit on Biology and Molecular Anthropology Applied to Development and 
      Health, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
AD  - High School for Health Sciences and Technicals, University of Tunis El-Manar, 
      Tunis, Tunisia.
FAU - Bouden, B
AU  - Bouden B
AD  - Research Unit on Biology and Molecular Anthropology Applied to Development and 
      Health, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
FAU - Haj Khelil, A
AU  - Haj Khelil A
AD  - Research Unit on Biology and Molecular Anthropology Applied to Development and 
      Health, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
FAU - Ben Chibani, J
AU  - Ben Chibani J
AD  - Research Unit on Biology and Molecular Anthropology Applied to Development and 
      Health, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
FAU - Hamdaoui, M H
AU  - Hamdaoui MH
AD  - Research Unit on the Antioxidant Compounds, Oxidative Stress, Trace Elements and 
      Metabolic Diseases.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160404
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Coffee)
RN  - EC 1.14.14.1 (CYP1A2 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Asian People
MH  - Case-Control Studies
MH  - *Coffee
MH  - Cytochrome P-450 CYP1A2/*genetics
MH  - Drinking/ethnology/*genetics
MH  - Drinking Behavior
MH  - Feeding Behavior/*ethnology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Sex Factors
MH  - White People
EDAT- 2016/05/14 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/05/14 06:00
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
AID - gmr7487 [pii]
AID - 10.4238/gmr.15027487 [doi]
PST - epublish
SO  - Genet Mol Res. 2016 Apr 4;15(2). doi: 10.4238/gmr.15027487.