PMID- 27173440
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20170817
IS  - 1360-046X (Electronic)
IS  - 0268-8697 (Linking)
VI  - 30
IP  - 5
DP  - 2016 Oct
TI  - Impact of 1p/19q codeletion on the diagnosis and prognosis of different grades of 
      meningioma.
PG  - 571-6
LID - 10.1080/02688697.2016.1181155 [doi]
AB  - BACKGROUND: Meningiomas are one of the most common tumours to affect the central 
      nervous system. Genetic mutations are important in meningeal tumourigenesis, 
      progression and prognosis. In this study, we aimed to examine the effect of 
      1p/19q deletion on the diagnosis and prognosis of meningioma subtypes using the 
      fluorescence in situ hybridization (FISH) method. METHODS: Twenty-four patients 
      with meningioma were retrospectively studied. Tumour samples were obtained from 
      10 typical, 11 atypical and three anaplastic malignant meningiomas. The most 
      representative tumour sections were screened for 1p/19q deletion using the FISH 
      method. RESULTS: Of the 24 patients, eight were women (33.3%) and 16 (66.7%) were 
      men. The mean age was 56.6 years. The higher-grade meningioma was usually seen in 
      males and had a higher rate of deletion on 1p (p = 0.001). There was a 
      statistically significant difference between the grades and the rate of deletion 
      on 19q (p = 0.042) and between the grades and the rates of polysomy, monosomy and 
      amplification on 19q (p = 0.002; p = 0.001; p = 0.002, respectively). There was 
      no statistical difference between 1p/19q codeletion and the grades of meningioma 
      (p > 0.05). We detected higher level of Ki-67 in the condition of codeletion but 
      did not find a statistical difference (p = 0.0553). CONCLUSION: Deletion on 1p, 
      as well as deletion, polysomy, monosomy and amplification on 19q, are detected 
      more frequently in high grade meningiomas. This amplification is most likely due 
      to the amplification of oncogenes.
FAU - Basaran, Recep
AU  - Basaran R
AD  - a Department of Neurosurgery , Istanbul Medeniyet University, Goztepe Education 
      and Research Hospital , Istanbul , Turkey ;
FAU - Uslu, Serap
AU  - Uslu S
AD  - b Department of Histology and Embryology , Istanbul Medeniyet University School 
      of Medicine , Istanbul , Turkey ;
FAU - Gucluer, Berrin
AU  - Gucluer B
AD  - c Department of Pathology , Istanbul Medeniyet University, Goztepe Education and 
      Research Hospital , Istanbul , Turkey ;
FAU - Onoz, Mustafa
AU  - Onoz M
AD  - d Department of Neurosurgery , Memorial Hospital , Istanbul , Turkey ;
FAU - Isik, Nejat
AU  - Isik N
AD  - a Department of Neurosurgery , Istanbul Medeniyet University, Goztepe Education 
      and Research Hospital , Istanbul , Turkey ;
FAU - Tiryaki, Mehmet
AU  - Tiryaki M
AD  - e Department of Neurosurgery , Dr. Lutfi Kirdar Kartal Education and Research 
      Hospital , Istanbul , Turkey ;
FAU - Yakicier, Cengiz
AU  - Yakicier C
AD  - f Department of Molecular Genetics, Acibadem University School of Medicine , 
      Istanbul , Turkey ;
FAU - Sav, Aydin
AU  - Sav A
AD  - g Department of Pathology, Acibadem University School of Medicine , Istanbul , 
      Turkey.
FAU - Elmaci, Ilhan
AU  - Elmaci I
AD  - d Department of Neurosurgery , Memorial Hospital , Istanbul , Turkey ;
LA  - eng
PT  - Journal Article
DEP - 20160513
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
RN  - 0 (Ki-67 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 19/*genetics
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Ki-67 Antigen/analysis
MH  - Male
MH  - Meningioma/*diagnosis/*genetics/therapy
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Prognosis
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - 1p/19q
OT  - Codeletion
OT  - FISH
OT  - meningioma
OT  - oncogene
OT  - prognosis
EDAT- 2016/05/14 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/05/14 06:00
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - 10.1080/02688697.2016.1181155 [doi]
PST - ppublish
SO  - Br J Neurosurg. 2016 Oct;30(5):571-6. doi: 10.1080/02688697.2016.1181155. Epub 
      2016 May 13.