PMID- 27173818
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20181202
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 26
IP  - 12
DP  - 2016 Dec
TI  - NSAID Use after Bariatric Surgery: a Randomized Controlled Intervention Study.
PG  - 2880-2885
AB  - BACKGROUND: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) should be 
      avoided in bariatric surgery patients. If use of an NSAID is inevitable, a proton 
      pump inhibitor (PPI) should also be used. AIM: To determine the effect of an, 
      compared to care-as-usual, additional intervention to reduce NSAID use in 
      patients who underwent bariatric surgery, and to determine the use of PPIs in 
      patients who use NSAIDs after bariatric surgery. METHODS: A randomized controlled 
      intervention study in patients after bariatric surgery. Patients were randomized 
      to an intervention or a control group. The intervention consisted of sending a 
      letter to patients and their general practitioners on the risks of use of NSAIDs 
      after bariatric surgery and the importance of avoiding NSAID use. The control 
      group received care-as-usual. Dispensing data of NSAIDs and PPIs were collected 
      from patients' pharmacies: from a period of 6 months before and from 3 until 
      9 months after the intervention. RESULTS: Two hundred forty-eight patients were 
      included (intervention group: 124; control group: 124). The number of users of 
      NSAIDs decreased from 22 to 18 % in the intervention group and increased from 20 
      to 21 % in the control group (NS). The use of a PPI with an NSAID rose from 52 to 
      55 % in the intervention group, and from 52 to 69 % in the control group (NS). 
      CONCLUSIONS: Informing patients and their general practitioners by letter, in 
      addition to care-as-usual, is not an effective intervention to reduce the use of 
      NSAIDs after bariatric surgery (trial number NTR3665).
FAU - Yska, Jan Peter
AU  - Yska JP
AD  - Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre 
      Leeuwarden, Leeuwarden, Netherlands. j.p.yska@znb.nl.
FAU - Gertsen, Sanneke
AU  - Gertsen S
AD  - Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre 
      Leeuwarden, Leeuwarden, Netherlands.
FAU - Flapper, Gerbrich
AU  - Flapper G
AD  - Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre 
      Leeuwarden, Leeuwarden, Netherlands.
FAU - Emous, Marloes
AU  - Emous M
AD  - Department of Surgery, Medical Centre Leeuwarden, Leeuwarden, Netherlands.
FAU - Wilffert, Bob
AU  - Wilffert B
AD  - Department of Pharmacotherapy, -Epidemiology and Economics, Department of 
      Pharmacy, University of Groningen, Groningen, Netherlands.
AD  - Department of Clinical Pharmacy and Pharmacology, University Medical Center 
      Groningen, University of Groningen, Groningen, Netherlands.
FAU - van Roon, Eric N
AU  - van Roon EN
AD  - Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre 
      Leeuwarden, Leeuwarden, Netherlands.
AD  - Department of Pharmacotherapy, -Epidemiology and Economics, Department of 
      Pharmacy, University of Groningen, Groningen, Netherlands.
LA  - eng
SI  - NTR/NTR3665
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - *Bariatric Surgery/adverse effects/rehabilitation
MH  - Comorbidity
MH  - Contraindications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/complications/drug therapy/*epidemiology/*surgery
MH  - Patient Education as Topic/methods
MH  - Postoperative Complications/epidemiology/prevention & control
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Risk Factors
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Drug safety
OT  - Intervention
OT  - NSAID
OT  - Proton pump inhibitor
EDAT- 2016/05/14 06:00
MHDA- 2017/11/03 06:00
CRDT- 2016/05/14 06:00
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2016/05/14 06:00 [entrez]
AID - 10.1007/s11695-016-2218-9 [pii]
AID - 10.1007/s11695-016-2218-9 [doi]
PST - ppublish
SO  - Obes Surg. 2016 Dec;26(12):2880-2885. doi: 10.1007/s11695-016-2218-9.