PMID- 27173979
OWN - NLM
STAT- MEDLINE
DCOM- 20170623
LR  - 20220311
IS  - 1432-1998 (Electronic)
IS  - 0301-0449 (Linking)
VI  - 46
IP  - 10
DP  - 2016 Sep
TI  - Comparison of left ventricular function assessment between echocardiography and 
      MRI in Duchenne muscular dystrophy.
PG  - 1399-408
LID - 10.1007/s00247-016-3622-y [doi]
AB  - BACKGROUND: Cardiomyopathy in Duchenne muscular dystrophy (DMD) is associated 
      with death in approximately 40% of patients. Echocardiography is routinely used 
      to assess left ventricular (LV) function; however, it has limitations in these 
      patients. OBJECTIVE: We compared echocardiographic measures of cardiac function 
      assessment to cardiac MRI. MATERIALS AND METHODS: We included children and young 
      adults with DMD who had MRI performed between January 2010 and July 2015. We 
      measured echocardiographic and MRI parameters of function assessment, including 
      strain. Presence of late gadolinium enhancement (LGE) was assessed by MRI. 
      Subjects were divided into two groups based on MRI left ventricular ejection 
      fraction (LVEF): group I, LVEF >/=55% and group II, LVEF <55%. RESULTS: We included 
      41 studies in 33 subjects, with 25 in group I and 16 in group II. Mean age of 
      subjects was 13.6 +/- 2.8 years and mean duration between echocardiogram and MRI 
      was 7.6 +/- 4.1 months. Only 8 of 16 (50%) patients in group II had diminished 
      function on echocardiogram. Echocardiographic images were suboptimal in 16 
      subjects (39%). Overall, echocardiographic parameters had weak correlation with 
      MRI-derived ejection fraction percentage. MRI-derived myocardial strain 
      assessment has better correlation with MRI ejection fraction as compared to 
      echocardiography-derived strain parameters. CONCLUSION: Echocardiography-based 
      ventricular functional assessment has weak correlation with MRI parameters in 
      children and young adults with Duchenne muscular dystrophy. While this 
      correlation improves in the subset of subjects with adequate echocardiographic 
      image quality, it remains modest and potentially suboptimal for clinical 
      management. Accordingly, we conclude that MRI should be performed routinely and 
      early in children with DMD, not only for LGE imaging but also for functional 
      assessment.
FAU - Buddhe, Sujatha
AU  - Buddhe S
AD  - Division of Cardiology, Department of Pediatrics, University of Washington School 
      of Medicine and Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 
      98105, USA. sujatha.buddhe@seattlechildrens.org.
FAU - Lewin, Mark
AU  - Lewin M
AD  - Division of Cardiology, Department of Pediatrics, University of Washington School 
      of Medicine and Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 
      98105, USA.
FAU - Olson, Aaron
AU  - Olson A
AD  - Division of Cardiology, Department of Pediatrics, University of Washington School 
      of Medicine and Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 
      98105, USA.
FAU - Ferguson, Mark
AU  - Ferguson M
AD  - Department of Radiology, University of Washington School of Medicine and Seattle 
      Children's Hospital, Seattle, WA, USA.
FAU - Soriano, Brian D
AU  - Soriano BD
AD  - Division of Cardiology, Department of Pediatrics, University of Washington School 
      of Medicine and Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 
      98105, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160512
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Echocardiography
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Muscular Dystrophy, Duchenne/*diagnostic imaging
MH  - Ventricular Dysfunction, Left/*diagnostic imaging
MH  - Young Adult
OTO - NOTNLM
OT  - Children
OT  - Duchenne muscular dystrophy
OT  - Echocardiography
OT  - Magnetic resonance imaging
OT  - Strain analysis
EDAT- 2016/05/14 06:00
MHDA- 2017/06/24 06:00
CRDT- 2016/05/14 06:00
PHST- 2015/12/03 00:00 [received]
PHST- 2016/03/30 00:00 [accepted]
PHST- 2016/02/23 00:00 [revised]
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/06/24 06:00 [medline]
AID - 10.1007/s00247-016-3622-y [pii]
AID - 10.1007/s00247-016-3622-y [doi]
PST - ppublish
SO  - Pediatr Radiol. 2016 Sep;46(10):1399-408. doi: 10.1007/s00247-016-3622-y. Epub 
      2016 May 12.