PMID- 27174209
OWN - NLM
STAT- MEDLINE
DCOM- 20170811
LR  - 20210114
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 41
IP  - 7
DP  - 2016 Jul
TI  - Biochemical Basis of Sestrin Physiological Activities.
PG  - 621-632
LID - S0968-0004(16)30023-8 [pii]
LID - 10.1016/j.tibs.2016.04.005 [doi]
AB  - Excessive accumulation of reactive oxygen species (ROS) and chronic activation of 
      mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized 
      promoters of aging and age-associated degenerative pathologies. Sestrins, a 
      family of highly conserved stress-inducible proteins, are important negative 
      regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic 
      basis of how Sestrins suppress these pathways remains elusive. In the past couple 
      of years, breakthrough discoveries about Sestrin signaling and its molecular 
      nature have markedly increased our biochemical understanding of Sestrin function. 
      These discoveries have also uncovered new potential therapeutic strategies that 
      may eventually enable us to attenuate aging and age-associated diseases.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Ho, Allison
AU  - Ho A
AD  - Department of Molecular and Integrative Physiology, University of Michigan, Ann 
      Arbor, MI 48109, USA.
FAU - Cho, Chun-Seok
AU  - Cho CS
AD  - Department of Molecular and Integrative Physiology, University of Michigan, Ann 
      Arbor, MI 48109, USA.
FAU - Namkoong, Sim
AU  - Namkoong S
AD  - Department of Molecular and Integrative Physiology, University of Michigan, Ann 
      Arbor, MI 48109, USA.
FAU - Cho, Uhn-Soo
AU  - Cho US
AD  - Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, 
      USA.
FAU - Lee, Jun Hee
AU  - Lee JH
AD  - Department of Molecular and Integrative Physiology, University of Michigan, Ann 
      Arbor, MI 48109, USA. Electronic address: leeju@umich.edu.
LA  - eng
GR  - R01 DK102850/DK/NIDDK NIH HHS/United States
GR  - R21 AG045432/AG/NIA NIH HHS/United States
GR  - T32 GM008322/GM/NIGMS NIH HHS/United States
GR  - P30 DK020572/DK/NIDDK NIH HHS/United States
GR  - R21 AG050903/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160510
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (SESN1 protein, human)
RN  - 0 (SESN2 protein, human)
RN  - 0 (SESN3 protein, human)
SB  - IM
MH  - Biochemical Phenomena
MH  - Heat-Shock Proteins/chemistry/*metabolism
MH  - Humans
MH  - Nuclear Proteins/chemistry/*metabolism
PMC - PMC4930368
MID - NIHMS782865
OTO - NOTNLM
OT  - ROS
OT  - Sestrin
OT  - aging
OT  - leucine
OT  - mTOR
OT  - structure
EDAT- 2016/05/14 06:00
MHDA- 2017/08/12 06:00
PMCR- 2017/07/01
CRDT- 2016/05/14 06:00
PHST- 2016/02/15 00:00 [received]
PHST- 2016/04/21 00:00 [revised]
PHST- 2016/04/22 00:00 [accepted]
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/08/12 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - S0968-0004(16)30023-8 [pii]
AID - 10.1016/j.tibs.2016.04.005 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2016 Jul;41(7):621-632. doi: 10.1016/j.tibs.2016.04.005. Epub 
      2016 May 10.