PMID- 27174326
OWN - NLM
STAT- MEDLINE
DCOM- 20170210
LR  - 20221207
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 129
IP  - 10
DP  - 2016 May 20
TI  - Association of Common Genetic Variants in Mitogen-activated Protein Kinase Kinase 
      Kinase Kinase 4 with Type 2 Diabetes Mellitus in a Chinese Han Population.
PG  - 1179-84
LID - 10.4103/0366-6999.181969 [doi]
AB  - BACKGROUND: A study has identified several novel susceptibility variants of the 
      mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) gene for type 2 
      diabetes mellitus (T2DM) within the German population. Among the variants, five 
      single nucleotide polymorphisms (SNPs) of MAP4K4 (rs1003376, rs11674694, 
      rs2236935, rs2236936, and rs6543087) showed significant association with T2DM or 
      diabetes-related quantitative traits. We aimed to evaluate whether common SNPs in 
      the MAP4K4 gene were associated with T2DM in the Chinese population. METHODS: 
      Five candidate SNPs were genotyped in 996 patients newly diagnosed with T2DM and 
      in 976 control subjects, using the SNPscan method. All subjects were recruited 
      from the Second Affiliated Hospital, Harbin Medical University from October 2010 
      to September 2013. We evaluated the T2DM risk conferred by individual SNPs and 
      haplotypes using logistic analysis, and the association between the five SNPs and 
      metabolic traits in the subgroups. RESULTS: Of the five variants, SNP 
      rs2236935T/C was significantly associated with T2DM in this study population 
      (odds ratio = 1.293; 95% confidence interval: 1.034-1.619, P= 0.025). In 
      addition, among the controls, rs1003376 was significantly associated with an 
      increased body mass index (P = 0.045) and homeostatic model assessment-insulin 
      resistance (P = 0.037). CONCLUSIONS: MAP4K4 gene is associated with T2DM in a 
      Chinese Han population, and MAP4K4 gene variants may contribute to the risk 
      toward the development of T2DM.
FAU - Li, Ting-Ting
AU  - Li TT
AD  - Department of Endemic Disease, The Second Affiliated Hospital, Harbin Medical 
      University, Harbin, Heilongjiang 150081, China.
FAU - Qiao, Hong
AU  - Qiao H
AD  - Department of Endemic Disease, The Second Affiliated Hospital, Harbin Medical 
      University, Harbin, Heilongjiang 150081, China.
FAU - Tong, Hui-Xin
AU  - Tong HX
AD  - Department of Endemic Disease, The Second Affiliated Hospital, Harbin Medical 
      University, Harbin, Heilongjiang 150081, China.
FAU - Zhuang, Tian-Wei
AU  - Zhuang TW
AD  - Department of Endemic Disease, The Second Affiliated Hospital, Harbin Medical 
      University, Harbin, Heilongjiang 150081, China.
FAU - Wang, Tong-Tong
AU  - Wang TT
AD  - Department of Endemic Disease, The Second Affiliated Hospital, Harbin Medical 
      University, Harbin, Heilongjiang 150081, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.1.11 (MAP4K4 protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Diabetes Mellitus, Type 2/*enzymology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Protein Serine-Threonine Kinases/*genetics
PMC - PMC4878163
EDAT- 2016/05/14 06:00
MHDA- 2017/02/12 06:00
PMCR- 2016/05/20
CRDT- 2016/05/14 06:00
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/02/12 06:00 [medline]
PHST- 2016/05/20 00:00 [pmc-release]
AID - ChinMedJ_2016_129_10_1179_181969 [pii]
AID - CMJ-129-1179 [pii]
AID - 10.4103/0366-6999.181969 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2016 May 20;129(10):1179-84. doi: 10.4103/0366-6999.181969.