PMID- 27174824
OWN - NLM
STAT- MEDLINE
DCOM- 20170228
LR  - 20181202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 156
DP  - 2016 Aug
TI  - Perfluoroalkyl substances in cord blood and attention deficit/hyperactivity 
      disorder symptoms in seven-year-old children.
PG  - 118-127
LID - S0045-6535(16)30592-6 [pii]
LID - 10.1016/j.chemosphere.2016.04.102 [doi]
AB  - OBJECTIVE: The effect of perfluoroalkyl substances (PFASs) on the development of 
      neurotoxicity in children is still controversial. This study aimed to evaluate 
      the association between in utero exposure to four PFASs and the development of 
      neurobehavioral symptoms related to attention deficit hyperactivity disorder 
      (ADHD) in early childhood. METHODS: Eligible study subjects were selected from 
      the Taiwan Birth Panel Study and the Taiwan Early-Life Cohort, which enrolled a 
      total of 1526 mother-infant pairs during 2004 and 2005. We collected umbilical 
      cord blood and analyzed perfluorooctanoic acid (PFOA), perfluorooctanyl sulfonate 
      (PFOS), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) 
      levels. When a child was 7 years old, to evaluate ADHD related neurobehavioral 
      symptoms, their parents completed the Swanson, Nolan, and Pelham IV scale 
      (SNAP-IV), the Child Behavior Checklist (CBCL), and the Strengths and 
      Difficulties Questionnaire (SDQ) questionnaires. We used linear regression models 
      with inverse probability weighting to explore the association between prenatal 
      exposure to four PFASs and ADHD rating scores. RESULTS: A total of 282 subjects 
      have completed the PFASs analysis and questionnaire survey. After adjusted for 
      potential confounders, we observed that PFNA is inversely associated with 
      inattention and oppositional defiant disorder of SNAP-IV, and 
      hyperactivity/inattention of SDQ. No association between PFOA, PFOS, or PFUA and 
      ADHD symptoms was found. CONCLUSIONS: Prenatal exposure to PFNA was found to 
      associate with neurobehavioral symptoms related to ADHD among Asian 
      seven-year-old children. Further studies are needed to elucidate the causal 
      relationship.
CI  - Copyright (c) 2016. Published by Elsevier Ltd.
FAU - Lien, Guang-Wen
AU  - Lien GW
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan.
FAU - Huang, Ching-Chun
AU  - Huang CC
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan; Department of Environmental 
      and Occupational Medicine, National Taiwan University College of Medicine and 
      National Taiwan University Hospital, Taipei, Taiwan.
FAU - Shiu, Jia-Shian
AU  - Shiu JS
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan.
FAU - Chen, Mei-Huei
AU  - Chen MH
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan.
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
AD  - Department of Pediatrics, National Taiwan University Hospital and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Guo, Yue-Liang
AU  - Guo YL
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan; Department of Environmental 
      and Occupational Medicine, National Taiwan University College of Medicine and 
      National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chen, Pau-Chung
AU  - Chen PC
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan; Department of Environmental 
      and Occupational Medicine, National Taiwan University College of Medicine and 
      National Taiwan University Hospital, Taipei, Taiwan; Department of Public Health, 
      National Taiwan University College of Public Health, Taipei, Taiwan. Electronic 
      address: pchen@ntu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20160509
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
RN  - 947VD76D3L (perfluorooctanoic acid)
SB  - IM
MH  - Attention Deficit Disorder with Hyperactivity/chemically 
      induced/diagnosis/*epidemiology
MH  - Caprylates/*adverse effects/*blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Fluorocarbons/*adverse effects/*blood
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Mothers
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/diagnosis/*epidemiology
MH  - Surveys and Questionnaires
MH  - Taiwan/epidemiology
OTO - NOTNLM
OT  - ADHD
OT  - CBCL
OT  - PFNA
OT  - PFOA
OT  - PFOS
OT  - Prenatal exposure
OT  - SDQ
OT  - SNAP-IV
EDAT- 2016/05/14 06:00
MHDA- 2017/03/01 06:00
CRDT- 2016/05/14 06:00
PHST- 2015/11/06 00:00 [received]
PHST- 2016/04/12 00:00 [revised]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/03/01 06:00 [medline]
AID - S0045-6535(16)30592-6 [pii]
AID - 10.1016/j.chemosphere.2016.04.102 [doi]
PST - ppublish
SO  - Chemosphere. 2016 Aug;156:118-127. doi: 10.1016/j.chemosphere.2016.04.102. Epub 
      2016 May 9.