PMID- 27175286
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160513
LR  - 20231111
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 3
IP  - 1
DP  - 2016
TI  - Ventricular longitudinal function is associated with microvascular obstruction 
      and intramyocardial haemorrhage.
PG  - e000337
LID - 10.1136/openhrt-2015-000337 [doi]
LID - e000337
AB  - BACKGROUND: Microvascular obstruction (MVO) and intramyocardial haemorrhage (IMH) 
      are associated with adverse prognosis, independently of infarct size after 
      reperfused ST-elevation myocardial infarction (STEMI). Mitral annular plane 
      systolic excursion (MAPSE) is a well-established parameter of longitudinal 
      function on echocardiography. OBJECTIVE: We aimed to investigate how acute MAPSE, 
      assessed by a four-chamber cine-cardiovascular MR (CMR), is associated with MVO, 
      IMH and convalescent left ventricular (LV) remodelling. METHODS: 54 consecutive 
      patients underwent CMR at 3T (Intera CV, Philips Healthcare, Best, The 
      Netherlands) within 3 days of reperfused STEMI. Cine, T2-weighted, T2* and late 
      gadolinium enhancement (LGE) imaging were performed. Infarct and MVO extent were 
      measured from LGE images. The presence of IMH was investigated by combined 
      analysis of T2w and T2* images. Averaged-MAPSE (medial-MAPSE+lateral-MAPSE/2) was 
      calculated from 4-chamber cine imaging. RESULTS: 44 patients completed the 
      baseline scan and 38 patients completed 3-month scans. 26 (59%) patients had MVO 
      and 25 (57%) patients had IMH. Presence of MVO and IMH were associated with lower 
      averaged-MAPSE (11.7+/-0.4 mm vs 9.3+/-0.3 mm; p<0.001 and 11.8+/-0.4 mm vs 9.2+/-0.3 mm; 
      p<0.001, respectively). IMH (beta=-0.655, p<0.001) and MVO (beta=-0.567, p<0.001) 
      demonstrated a stronger correlation to MAPSE than other demographic and infarct 
      characteristics. MAPSE </=10.6 mm demonstrated 89% sensitivity and 72% specificity 
      for the detection of MVO and 92% sensitivity and 74% specificity for IMH. LV 
      remodelling in convalescence was not associated with MAPSE (AUC 0.62, 95% CI 0.44 
      to 0.77, p=0.22). CONCLUSIONS: Postreperfused STEMI, LV longitudinal function 
      assessed by MAPSE can independently predict the presence of MVO and IMH.
FAU - Garg, Pankaj
AU  - Garg P
AUID- ORCID: 0000-0002-5483-169X
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Kidambi, Ananth
AU  - Kidambi A
AUID- ORCID: 0000-0002-0939-7900
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Foley, James R J
AU  - Foley JR
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Musa, Tarique Al
AU  - Musa TA
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Ripley, David P
AU  - Ripley DP
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Swoboda, Peter P
AU  - Swoboda PP
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Erhayiem, Bara
AU  - Erhayiem B
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Dobson, Laura E
AU  - Dobson LE
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - McDiarmid, Adam K
AU  - McDiarmid AK
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Greenwood, John P
AU  - Greenwood JP
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
FAU - Plein, Sven
AU  - Plein S
AD  - Multidisciplinary Cardiovascular Research Centre & Leeds Institute of 
      Cardiovascular and Metabolic Medicine, University of Leeds , Leeds , UK.
LA  - eng
GR  - FS/10/62/28409/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160502
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC4860848
EDAT- 2016/05/14 06:00
MHDA- 2016/05/14 06:01
PMCR- 2016/05/02
CRDT- 2016/05/14 06:00
PHST- 2015/09/16 00:00 [received]
PHST- 2016/01/25 00:00 [revised]
PHST- 2016/02/23 00:00 [accepted]
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2016/05/14 06:01 [medline]
PHST- 2016/05/02 00:00 [pmc-release]
AID - openhrt-2015-000337 [pii]
AID - 10.1136/openhrt-2015-000337 [doi]
PST - epublish
SO  - Open Heart. 2016 May 2;3(1):e000337. doi: 10.1136/openhrt-2015-000337. 
      eCollection 2016.