PMID- 27176146
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20220331
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 38
IP  - 1
DP  - 2016 Jul
TI  - Correlation of 5-HTT, BDNF and NPSR1 gene polymorphisms with anxiety and 
      depression in asthmatic patients.
PG  - 65-74
LID - 10.3892/ijmm.2016.2581 [doi]
AB  - Asthmatic patients are known to have a higher risk of anxiety and depression. In 
      the present study, we aimed to explore the association of serotonin 
      transporter (5-HTT), brain-derived neurotrophic factor (BDNF) and neuropeptide S 
      receptor 1 (NPSR1) gene polymorphisms with anxiety and depression in asthmatic 
      patients. This was a cross-sectional study conducted on 143 asthmatic patients 
      and 175 healthy volunteers. Of the asthmatic patients, 49 suffered from anxiety 
      and 12 exhibited signs of depression. Patients with a lower level of education 
      were more prone to depression. Both anxiety and depression were associated with 
      poor asthma control as evaluated by the Asthma Control Test (ACT) score. The 
      association of single nucleotide polymorphisms of BDNF, NPSR1 and 5-HTT with 
      anxiety and depression in asthamtic patients was evaluated. The distribution of 
      5-HTT gene polymorphisms in the healthy group, the group with asthma but without 
      anxiety, and the group with asthma and anxiety had significant differences. 
      Females with asthma and anxiety were more prone to BDNF polymorphism. Also, BDNF 
      gene distribution exhibited significant differences among those in the healthy 
      group, the group with asthma but no depression, and the group with asthma and 
      depression; however, NPSR1 gene distribution did not vary greatly between the 
      groups. The anxiety score was significantly affected by the interaction between 
      5-HTT (LL, S+) and BDNF (A+, GG) (H=5.99, P=0.015). The depression score was 
      significantly affected by the interaction between BDNF (A+, GG) and NPSR1 (AA, 
      T+). We noted that both anxiety and depression led to poor asthma control. The 
      interaction between 5-HTT (LL) and BDNF (A+) increased the risk of anxiety, and 
      the interaction between BDNF (A+, GG) and NPSR1 (AA, T+) increased the risk of 
      depression in asthmatic patients.
FAU - Yang, Yuan
AU  - Yang Y
AD  - Department of Respiratory Medicine, Zhongda Hospital Affiliated to Southeast 
      University, Nanjing, Jiangsu 210009, P.R. China.
FAU - Zhao, Mingzhe
AU  - Zhao M
AD  - Medical College of Southeast University, Nanjing, Jiangsu 210009, P.R. China.
FAU - Zhang, Yuqun
AU  - Zhang Y
AD  - Department of Psychosomatics and Psychiatry, Zhongda Hospital Affiliated to 
      Southeast University, Nanjing, Jiangsu 210009, P.R. China.
FAU - Shen, Xinhua
AU  - Shen X
AD  - Department of Neurosis and Psychosomatic Diseases, Huzhou 3rd Hospital, Huzhou, 
      Zhejiang 313000, P.R. China.
FAU - Yuan, Yonggui
AU  - Yuan Y
AD  - Department of Psychosomatics and Psychiatry, Zhongda Hospital Affiliated to 
      Southeast University, Nanjing, Jiangsu 210009, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160509
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NPSR1 protein, human)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Anxiety/complications/*genetics
MH  - Asthma/complications/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Depression/complications/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Receptors, G-Protein-Coupled/*genetics
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
PMC - PMC4899034
EDAT- 2016/05/14 06:00
MHDA- 2017/03/07 06:00
PMCR- 2016/05/09
CRDT- 2016/05/14 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2016/04/15 00:00 [accepted]
PHST- 2016/05/14 06:00 [entrez]
PHST- 2016/05/14 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
PHST- 2016/05/09 00:00 [pmc-release]
AID - ijmm-38-01-0065 [pii]
AID - 10.3892/ijmm.2016.2581 [doi]
PST - ppublish
SO  - Int J Mol Med. 2016 Jul;38(1):65-74. doi: 10.3892/ijmm.2016.2581. Epub 2016 May 
      9.