PMID- 27177469
OWN - NLM
STAT- MEDLINE
DCOM- 20171129
LR  - 20220321
IS  - 1432-0932 (Electronic)
IS  - 0940-6719 (Linking)
VI  - 25
IP  - 11
DP  - 2016 Nov
TI  - Do Modic changes have an impact on clinical outcome in lumbar spine surgery? A 
      systematic literature review.
PG  - 3735-3745
AB  - PURPOSE: To provide a systematic literature review of the impact of preoperative 
      Modic changes (MCs) on the clinical outcome following lumbar spine surgery for 
      degenerative lumbar spine disease. METHODS: A PubMed search until 31 October 2015 
      was performed to identify publications correlating preoperative MC with clinical 
      outcome in patients undergoing spine surgery. RESULTS: Inclusion criteria were 
      met by 14 articles (7 prospective and 7 retrospective studies) representing a 
      total of 1652 surgical patients, of which at least 804 (>49 %) showed MC. Of the 
      14 publications, 6 concerned discectomy (n = 607), 1 fusion versus discectomy 
      (n = 91), 3 fusion surgery (n = 454), and 4 total disc replacement (TDR, 
      n = 500). A trend toward less improvement in low back pain or Oswestry Disability 
      Index score was found in the discectomy studies, and a trend toward increased 
      improvement was demonstrated in the TDR studies when MC was present 
      preoperatively. The fusion studies were of low evidence, and showed conflicting 
      results. CONCLUSION: Preoperative MC showed a trend toward a negative correlation 
      with clinical improvement in patients undergoing discectomy for LDH and a 
      positive correlation with clinical improvement in patients undergoing TDR for 
      degenerative disc disease. However, it is questionable whether the differences 
      surpass the minimal clinically important difference (MCID). In patients 
      undergoing fusion surgery, there was insufficient evidence to draw any 
      conclusions. Future studies should include a larger patient material, focus on 
      MCID, and include known confounding factors of the clinical outcome of spine 
      surgery in the analysis.
FAU - Laustsen, Aske Foldbjerg
AU  - Laustsen AF
AD  - Department of Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Nordre 
      Ringvej 57, 2600, Glostrup, Denmark.
FAU - Bech-Azeddine, Rachid
AU  - Bech-Azeddine R
AD  - Department of Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Nordre 
      Ringvej 57, 2600, Glostrup, Denmark. rachid.bech-azeddine@regionh.dk.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20160513
PL  - Germany
TA  - Eur Spine J
JT  - European spine journal : official publication of the European Spine Society, the 
      European Spinal Deformity Society, and the European Section of the Cervical Spine 
      Research Society
JID - 9301980
SB  - IM
MH  - *Diskectomy
MH  - Humans
MH  - Intervertebral Disc/diagnostic imaging/*pathology/surgery
MH  - Intervertebral Disc Degeneration/diagnostic imaging/pathology/*surgery
MH  - Lumbar Vertebrae/diagnostic imaging/*pathology/surgery
MH  - Preoperative Period
MH  - *Spinal Fusion
MH  - *Total Disc Replacement
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clinical outcome
OT  - Fusion
OT  - Low back pain
OT  - Modic changes
OT  - Surgery
OT  - VESC
EDAT- 2016/10/28 06:00
MHDA- 2017/12/01 06:00
CRDT- 2016/05/15 06:00
PHST- 2016/02/28 00:00 [received]
PHST- 2016/05/08 00:00 [accepted]
PHST- 2016/05/08 00:00 [revised]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
PHST- 2016/05/15 06:00 [entrez]
AID - 10.1007/s00586-016-4609-y [pii]
AID - 10.1007/s00586-016-4609-y [doi]
PST - ppublish
SO  - Eur Spine J. 2016 Nov;25(11):3735-3745. doi: 10.1007/s00586-016-4609-y. Epub 2016 
      May 13.