PMID- 27177702
OWN - NLM
STAT- MEDLINE
DCOM- 20170125
LR  - 20221207
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 34
DP  - 2016 Jul
TI  - MMP3 -1171 5A/6A Promoter Genotype Influences Serum MMP3 Levels and Is Associated 
      with Deep Venous Thrombosis.
PG  - 261-7
LID - S0890-5096(16)30239-4 [pii]
LID - 10.1016/j.avsg.2015.11.039 [doi]
AB  - BACKGROUND: The aim of this study was to investigate the roles of MMP3 (matrix 
      metalloproteinase-3) gene polymorphism and protein expression in deep venous 
      thrombosis (DVT) among Chinese Han population. METHODS: A total of 280 subjects 
      were included in this study and categorized as case group (144 DVT patients) and 
      control group (136 healthy individuals). Polymerase chain reaction-restriction 
      fragment length polymorphism was used to detect MMP3 promoter -1171 5A>6A 
      genotype and allele frequencies. MMP3 serum levels were measured by enzyme-linked 
      immunosorbent assay. SPSS version 18.0 statistical software was used for data 
      analysis. RESULTS: There was significant difference in genotype frequencies of 
      MMP3 gene -1171 5A>6A between the case group and the control group (all 
      P < 0.05). Furthermore, the 6A allele on MMP3 -1171 5A>6A may be associated with 
      increased risk of DVT (odds ratio 1.961, 95% confidence interval 1.309-2.939, 
      P < 0.01). The MMP3 serum level in DVT patients was markedly higher than the 
      control group (case group: 28.45 +/- 10.97 vs. CONTROL GROUP: 18.18 +/- 9.03, 
      P < 0.05). Serum MMP3 level in DVT patients carrying 5A/6A and 6A/6A genotypes 
      was higher than the control group (P < 0.05). The bilateral calf circumference 
      difference was significantly higher in DVT patients than the control group among 
      all the genotypes at MMP3 gene -1171 5A>6A (all P < 0.05). CONCLUSION: MMP3 gene 
      -1171 5A>6A polymorphism and upregulated protein expression may be associated 
      with DVT risk in Chinese Han population.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Li, Xiang-Ping
AU  - Li XP
AD  - Department of Emergency Orthopedics, Linyi People's Hospital of Shandong 
      Province, Linyi, Shandong, P.R. China.
FAU - Wan, Guang-Zhen
AU  - Wan GZ
AD  - Department of Spine Surgery, North Medical District, Linyi People's Hospital of 
      Shandong Province, Linyi, Shandong, P.R. China.
FAU - Wang, Guang-Jian
AU  - Wang GJ
AD  - Department of Internal Medicine, Dai Gu Hospital of Mengyin County, Linyi, 
      Shandong, P.R. China.
FAU - Li, Jing-Fang
AU  - Li JF
AD  - Department of Cardiology, Linyi People's Hospital of Shandong Province, Linyi, 
      Shandong, P.R. China. Electronic address: lijingfang1021@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160510
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood/*genetics
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
MH  - Up-Regulation
MH  - Venous Thrombosis/blood/diagnostic imaging/*enzymology/*genetics
MH  - Young Adult
EDAT- 2016/05/15 06:00
MHDA- 2017/01/26 06:00
CRDT- 2016/05/15 06:00
PHST- 2015/06/10 00:00 [received]
PHST- 2015/10/21 00:00 [revised]
PHST- 2015/11/27 00:00 [accepted]
PHST- 2016/05/15 06:00 [entrez]
PHST- 2016/05/15 06:00 [pubmed]
PHST- 2017/01/26 06:00 [medline]
AID - S0890-5096(16)30239-4 [pii]
AID - 10.1016/j.avsg.2015.11.039 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2016 Jul;34:261-7. doi: 10.1016/j.avsg.2015.11.039. Epub 2016 May 
      10.