PMID- 27178039
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20181113
IS  - 1432-1173 (Electronic)
IS  - 0017-8470 (Linking)
VI  - 67
IP  - 6
DP  - 2016 Jun
TI  - [Autoimmune reactions in psoriasis : Spotlight].
PG  - 432-7
LID - 10.1007/s00105-016-3799-x [doi]
AB  - BACKGROUND: Psoriasis is a human leukocyte antigen (HLA)-associated 
      T‑cell-mediated disorder. OBJECTIVES: The role of the main psoriasis risk allele 
      HLA-C*06:02 in disease manifestation and the mechanisms which activate the 
      pathogenic T‑cell response in the skin of psoriasis patients remained elusive. 
      MATERIALS AND METHODS: Key to the immune pathogenesis of psoriasis was the 
      analysis of the specificity of the infiltrating lesional psoriatic CD8(+) T cells 
      RESULTS AND CONCLUSION: Analyses of the lesional psoriatic T‑cell reactivity 
      demonstrate that psoriasis is an autoimmune disease. It is based on an autoimmune 
      response against melanocytes which is preferentially mediated by HLA-C*06:02 
      through autoantigen presentation. Here we discuss the mechanisms of this 
      autoimmune response in the context of the polygenic psoriatic predisposition.
FAU - Prinz, J C
AU  - Prinz JC
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, Klinikum der Universitat 
      Munchen, Ludwig-Maximilians-Universitat, Frauenlobstr. 9-11, 80337, Munchen, 
      Deutschland. joerg.prinz@med.uni-muenchen.de.
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Autoimmunreaktionen bei Psoriasis : Spotlight.
PL  - Germany
TA  - Hautarzt
JT  - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
JID - 0372755
RN  - 0 (Autoantigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*01:06 antigen)
SB  - IM
MH  - Autoantigens/immunology
MH  - Autoimmune Diseases/*immunology
MH  - HLA-C Antigens/*immunology
MH  - Humans
MH  - Immunity, Innate/*immunology
MH  - Models, Immunological
MH  - Psoriasis/*immunology
MH  - Skin/*immunology
MH  - T-Lymphocytes/*immunology
OTO - NOTNLM
OT  - Autoantigen
OT  - Autoimmune disease
OT  - Melanocytes
OT  - Pathogenesis
OT  - Psoriasis vulgaris
EDAT- 2016/05/15 06:00
MHDA- 2017/03/07 06:00
CRDT- 2016/05/15 06:00
PHST- 2016/05/15 06:00 [entrez]
PHST- 2016/05/15 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
AID - 10.1007/s00105-016-3799-x [pii]
AID - 10.1007/s00105-016-3799-x [doi]
PST - ppublish
SO  - Hautarzt. 2016 Jun;67(6):432-7. doi: 10.1007/s00105-016-3799-x.