PMID- 27178547
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20191210
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 408
IP  - 18
DP  - 2016 Jul
TI  - A validated method for rapid determination of dibenzo-p-dioxins/furans (PCDD/Fs), 
      polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in 
      human milk: focus on utility of tandem solid phase extraction (SPE) cleanup.
PG  - 4897-906
LID - 10.1007/s00216-016-9576-y [doi]
AB  - An improved method based on tandem solid phase extraction (SPE) cleanup and gas 
      chromatography-high resolution mass spectrometry (GC-HRMS) has been validated for 
      a rapid determination of dibenzo-p-dioxins/furans (PCDD/Fs), dioxin-like 
      polychlorinated biphenyls (PCBs), marker polychlorinated biphenyls (M-PCBs), and 
      polybrominated diphenyl ethers (PBDEs) using a large volume (50 mL) of human 
      milk. This method was well validated for the measurement of these analytes in 
      human milk from the general population with low limits of detection (LODs, 
      0.004-0.12 ng/g lipid), satisfactory accuracy (75-120 % of recoveries), and 
      precision [less than 10 % of relative standard deviations (RSDs)]. To 
      comprehensively evaluate the performance of this method, a good, presently 
      validated and routinely used method based on an automated sample clean-up system 
      (ASCS, based on the commercial acid multilayer silica, basic alumina, and carbon 
      columns) was used in parallel for comparison. Compared with the ASCS method, this 
      method presented comparable specificity. Additionally, this method, in contrast 
      to ASCS method, highly reduced consumption of solvents (40 mL versus 500 mL), 
      which results in much lower background in the procedural blank, reduced time, and 
      enhanced sample pretreatment throughput. This method was also applied in a pilot 
      study to measure a batch of human milk samples with satisfactory results. 
      Graphical Abstract Characteristics of the application of tandem SPE cleanup for 
      determination of PCDD/Fs, DL-PCBs,M-PCBs and PBDEs in human milk.
FAU - Lin, Yuanjie
AU  - Lin Y
AD  - Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West 
      Road, Shanghai, 200336, China.
FAU - Feng, Chao
AU  - Feng C
AD  - Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West 
      Road, Shanghai, 200336, China.
FAU - Xu, Qian
AU  - Xu Q
AD  - Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West 
      Road, Shanghai, 200336, China.
FAU - Lu, Dasheng
AU  - Lu D
AD  - Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West 
      Road, Shanghai, 200336, China. ludasheng@scdc.sh.cn.
AD  - School of Public Health/MOE Key Lab for Public Health/Collaborative Innovation 
      Center of Social Risks Governance in Health, Fudan University, 130 Dong'an Road, 
      Shanghai, 200032, China. ludasheng@scdc.sh.cn.
FAU - Qiu, Xinlei
AU  - Qiu X
AD  - Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West 
      Road, Shanghai, 200336, China.
FAU - Jin, Yu'e
AU  - Jin Y
AD  - Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West 
      Road, Shanghai, 200336, China.
FAU - Wang, Guoquan
AU  - Wang G
AD  - Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan West 
      Road, Shanghai, 200336, China. wangguoquan@scdc.sh.cn.
FAU - Wang, Dongli
AU  - Wang D
AD  - California Department of Public Health, 850 Marina Bay Parkway, Richmond, CA, 
      94804, USA.
FAU - She, Jianwen
AU  - She J
AD  - California Department of Public Health, 850 Marina Bay Parkway, Richmond, CA, 
      94804, USA.
FAU - Zhou, Zhijun
AU  - Zhou Z
AD  - School of Public Health/MOE Key Lab for Public Health/Collaborative Innovation 
      Center of Social Risks Governance in Health, Fudan University, 130 Dong'an Road, 
      Shanghai, 200032, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Validation Study
DEP - 20160513
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Aromatic)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/*analysis
MH  - Food Analysis/*methods
MH  - Food Contamination/*analysis
MH  - Humans
MH  - Hydrocarbons, Aromatic/*analysis/chemistry
MH  - Milk/*chemistry
MH  - Polychlorinated Biphenyls
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Solid Phase Extraction/*methods
MH  - Specimen Handling/methods
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - GC-HRMS
OT  - Human milk
OT  - PBDEs
OT  - PCBs
OT  - PCDD/Fs
OT  - POPs
OT  - Tandem SPE
EDAT- 2016/05/15 06:00
MHDA- 2018/01/18 06:00
CRDT- 2016/05/15 06:00
PHST- 2016/01/26 00:00 [received]
PHST- 2016/04/18 00:00 [accepted]
PHST- 2016/03/24 00:00 [revised]
PHST- 2016/05/15 06:00 [entrez]
PHST- 2016/05/15 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
AID - 10.1007/s00216-016-9576-y [pii]
AID - 10.1007/s00216-016-9576-y [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2016 Jul;408(18):4897-906. doi: 10.1007/s00216-016-9576-y. 
      Epub 2016 May 13.