PMID- 27178973 OWN - NLM STAT- MEDLINE DCOM- 20171206 LR - 20190202 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 6 IP - 5 DP - 2016 May 13 TI - Economic evaluation of manual therapy for musculoskeletal diseases: a protocol for a systematic review and narrative synthesis of evidence. PG - e010556 LID - 10.1136/bmjopen-2015-010556 [doi] LID - e010556 AB - INTRODUCTION: Manual therapy is the non-surgical conservative management of musculoskeletal disorders using the practitioner's hands on the patient's body for diagnosing and treating disease. The aim of this study is to systematically review trial-based economic evaluations of manual therapy relative to other interventions used for the management of musculoskeletal diseases. METHODS AND ANALYSIS: Randomised clinical trials (RCTs) on the economic evaluation of manual therapy for musculoskeletal diseases will be included in the review. The following databases will be searched from their inception: Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Econlit, Mantis, Index to Chiropractic Literature, Science Citation Index, Social Science Citation Index, Allied and Complementary Medicine Database (AMED), Cochrane Database of Systematic Reviews (CDSR), National Health Service Database of Abstracts of Reviews of Effects (NHS DARE), National Health Service Health Technology Assessment Database (NHS HTA), National Health Service Economic Evaluation Database (NHS EED), CENTRAL, five Korean medical databases (Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Service System (RISS), DBPIA, Korean Traditional Knowledge Portal (KTKP) and KoreaMed) and three Chinese databases (China National Knowledge Infrastructure (CNKI), VIP and Wanfang). The evidence for the cost-effectiveness, cost-utility and cost-benefit of manual therapy for musculoskeletal diseases will be assessed as the primary outcome. Health-related quality of life and adverse effects will be assessed as secondary outcomes. We will critically appraise the included studies using the Cochrane risk of bias tool and the Drummond checklist. Results will be summarised using Slavin's qualitative best-evidence synthesis approach. ETHICS AND DISSEMINATION: The results of the study will be disseminated via a peer-reviewed journal and/or conference presentations. TRIAL REGISTRATION NUMBER: PROSPERO CRD42015026757. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ FAU - Kim, Chang-Gon AU - Kim CG AD - Department of Rehabilitation Medicine, College of Korean Medicine, Won-Kwang University, Iksan, Korea. FAU - Mun, Su-Jeong AU - Mun SJ AD - Mibyeong Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea. FAU - Kim, Ka-Na AU - Kim KN AD - Department of Neuropsychiatry, College of Korean Medicine, Kyung-Hee University, Seoul, Korea. FAU - Shin, Byung-Cheul AU - Shin BC AD - Third Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Yangsan, Korea. FAU - Kim, Nam-Kwen AU - Kim NK AD - Department of Ophthalmology, Otolaryngology and Dermatology, School of Korean Medicine, Pusan National University, Yangsan, Korea. FAU - Lee, Dong-Hyo AU - Lee DH AD - Evidence-Based Healthcare Research Collaborating Center, College of Korean Medicine, Woosuk University, Jeonju, Korea Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Woosuk University, Jeonju, Korea. FAU - Lee, Jung-Han AU - Lee JH AD - Department of Rehabilitation Medicine, College of Korean Medicine, Won-Kwang University, Iksan, Korea. LA - eng PT - Journal Article DEP - 20160513 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Cost-Benefit Analysis MH - Disability Evaluation MH - Humans MH - Musculoskeletal Diseases/diagnosis/economics/*therapy MH - Musculoskeletal Manipulations/*economics/methods MH - Pain Measurement MH - Randomized Controlled Trials as Topic MH - Systematic Reviews as Topic PMC - PMC4874156 OTO - NOTNLM OT - economic evaluation OT - manual therapy OT - musculoskeletal diseases OT - systematic review EDAT- 2016/05/15 06:00 MHDA- 2017/12/07 06:00 PMCR- 2016/05/13 CRDT- 2016/05/15 06:00 PHST- 2016/05/15 06:00 [entrez] PHST- 2016/05/15 06:00 [pubmed] PHST- 2017/12/07 06:00 [medline] PHST- 2016/05/13 00:00 [pmc-release] AID - bmjopen-2015-010556 [pii] AID - 10.1136/bmjopen-2015-010556 [doi] PST - epublish SO - BMJ Open. 2016 May 13;6(5):e010556. doi: 10.1136/bmjopen-2015-010556.