PMID- 27179834
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20220321
IS  - 2213-1787 (Electronic)
IS  - 2213-1779 (Linking)
VI  - 4
IP  - 8
DP  - 2016 Aug
TI  - Plasma Corin as a Predictor of Cardiovascular Events in Patients With Chronic 
      Heart Failure.
PG  - 664-9
LID - S2213-1779(16)30064-6 [pii]
LID - 10.1016/j.jchf.2016.03.006 [doi]
AB  - OBJECTIVES: The aim of this study was to determine the prognostic value of plasma 
      corin in patients with chronic heart failure (CHF). BACKGROUND: In recent years, 
      accumulating evidence has indicated that corin plays a critical role in 
      regulating blood pressure and cardiac function. METHODS: We enrolled 1,148 
      consecutive CHF patients in a prospective cohort study and explored the 
      association between plasma corin levels and clinical prognosis using multivariate 
      Cox regression analysis. RESULTS: Patients with low corin levels (<458 pg/ml) 
      were more likely to be women and to be hypertensive. Low corin was found to be 
      associated with an increase in New York Heart Association (NYHA) functional class 
      and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and a decrease 
      in left ventricular ejection fraction (LVEF) and the estimated glomerular 
      filtration rate (eGFR). Multivariate Cox regression analysis suggested that log 
      corin was an independent predictor of major adverse cardiac event(s) (MACE) 
      (hazard ratio: 0.62; 95% confidence interval: 0.39 to 0.95), together with age, 
      diabetes, NYHA functional class, LVEF, eGFR, and log NT-proBNP. In addition, log 
      corin was also a significant predictor for cardiovascular death (p = 0.041) and 
      heart failure rehospitalization (p = 0.015) after adjustment for clinical 
      variables and established biomarkers of adverse prognosis. The Kaplan-Meier 
      survival curves showed that low corin was a significant predictor of MACE in 
      patients with NT-proBNP levels above and below the median. CONCLUSIONS: Our study 
      demonstrates that plasma corin is a valuable prognostic marker of MACE in 
      patients with CHF, independent of established conventional risk factors.
CI  - Copyright (c) 2016 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Zhou, Xiang
AU  - Zhou X
AD  - Department of Cardiology, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China. Electronic address: zhou-xiang@suda.edu.cn.
FAU - Chen, Jian-Chang
AU  - Chen JC
AD  - Department of Cardiology, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Yang, Hui
AU  - Yang H
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Du, Kang
AU  - Du K
AD  - Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Kong, Yuan
AU  - Kong Y
AD  - Department of Epidemiology and Biostatistics, Nanjing Medical University, 
      Nanjing, China.
FAU - Xu, Xiao-Hua
AU  - Xu XH
AD  - Department of Epidemiology and Biostatistics, Nanjing Medical University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20160511
PL  - United States
TA  - JACC Heart Fail
JT  - JACC. Heart failure
JID - 101598241
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 3.4.21.- (CORIN protein, human)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
CIN - JACC Heart Fail. 2016 Aug;4(8):670-3. PMID: 27395344
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiovascular Diseases/*mortality
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*blood
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Serine Endopeptidases/*blood
MH  - Stroke Volume
OTO - NOTNLM
OT  - chronic heart failure
OT  - corin
OT  - major adverse cardiac events
EDAT- 2016/05/18 06:00
MHDA- 2018/01/06 06:00
CRDT- 2016/05/16 06:00
PHST- 2016/02/03 00:00 [received]
PHST- 2016/03/08 00:00 [revised]
PHST- 2016/03/10 00:00 [accepted]
PHST- 2016/05/16 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
AID - S2213-1779(16)30064-6 [pii]
AID - 10.1016/j.jchf.2016.03.006 [doi]
PST - ppublish
SO  - JACC Heart Fail. 2016 Aug;4(8):664-9. doi: 10.1016/j.jchf.2016.03.006. Epub 2016 
      May 11.