PMID- 27181214 OWN - NLM STAT- MEDLINE DCOM- 20170217 LR - 20221207 IS - 2040-1124 (Electronic) IS - 2040-1116 (Print) IS - 2040-1116 (Linking) VI - 7 IP - 4 DP - 2016 Jul TI - HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese. PG - 514-21 LID - 10.1111/jdi.12462 [doi] AB - AIMS/INTRODUCTION: To investigate the typing for human leukocyte antigen (HLA) class I in Chinese patients with type 1 diabetes as a complement screening for HLA class II. MATERIALS AND METHODS: A total of 212 type 1 diabetic patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA class I and II were examined with a high-resolution polymerase chain reaction sequence-based typing method. RESULTS: The haplotype, A*33:03-B*58:01-C*03:02(A33), was associated with type 1 diabetes (P = 1.0 x 10(-4) , odds ratio 3.2 [1.738-5.843]). The A33-DR3 and A33-DR9 haplotypes significantly enhanced the risk of type 1 diabetes (A33-DR3, odds ratio 5.1 [2.40-10.78], P = 4.0 x 10(-6) ; A33-DR9, odds ratio 13.0 [1.69-100.32], P = 0.004). In type 1 diabetic patients, compared with A33-DR3-negative carriers, A33-DR3-positive carriers had significantly lower percentages of CD3(+) CD4(+) T cells (42.5 +/- 7.72 vs 37.0 +/- 8.35%, P = 0.023), higher percentages of CD3(+) CD8(+) T cells (27.4 +/- 7.09 vs 32.8 +/- 5.98%, P = 0.005) and T-cell receptor alpha/beta T cells (70.0 +/- 7.00 vs 73.6 +/- 6.25%, P = 0.031), and lower CD4/CD8 ratios (1.71 +/- 0.75 vs 1.16 +/- 0.35, P = 0.003). CONCLUSIONS: It is the first time that the haplotypes A33-DR3 and A33-DR9 were found with an enhanced predisposition to type 1 diabetes in Han Chinese. A33-DR3 was associated with a reduction in the helper-to-cytotoxic cell ratio and preferential increase of T-cell receptor alpha/beta T cell. The typing for HLA class I and its immunogenetic effects are important for more accurate HLA class II haplotype risk prediction and etiology research in type 1 diabetic patients. CI - (c) 2015 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. FAU - Zhang, Juanjuan AU - Zhang J AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Zhao, Liebin AU - Zhao L AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Wang, Bokai AU - Wang B AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Gao, Jie AU - Gao J AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Wang, Li AU - Wang L AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Li, Li AU - Li L AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Cui, Bin AU - Cui B AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Hu, Min AU - Hu M AD - Center for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia. FAU - Hong, Jie AU - Hong J AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Gu, Weiqiong AU - Gu W AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Wang, Weiqing AU - Wang W AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. FAU - Ning, Guang AU - Ning G AD - Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai, China. AD - Laboratory for Endocrine & Metabolic Diseases, Institute of Health Science, Shanghai JiaoTong University, School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. LA - eng PT - Journal Article DEP - 20160503 PL - Japan TA - J Diabetes Investig JT - Journal of diabetes investigation JID - 101520702 RN - 0 (HLA Antigens) RN - 0 (HLA-DR Serological Subtypes) RN - 0 (HLA-DR3 Antigen) RN - 0 (HLA-DR9 antigen) SB - IM MH - Adult MH - Asian People MH - Diabetes Mellitus, Type 1/epidemiology/*genetics/*immunology MH - Female MH - Gene Frequency MH - *Genetic Predisposition to Disease MH - HLA Antigens/*genetics MH - HLA-DR Serological Subtypes/*genetics MH - HLA-DR3 Antigen/*genetics MH - Haplotypes MH - Humans MH - Male MH - Risk Factors MH - Young Adult PMC - PMC4931201 OTO - NOTNLM OT - Genetics OT - HLA-A*33 OT - Type 1 diabetes EDAT- 2016/05/18 06:00 MHDA- 2017/02/18 06:00 PMCR- 2016/07/01 CRDT- 2016/05/17 06:00 PHST- 2015/06/07 00:00 [received] PHST- 2015/12/13 00:00 [revised] PHST- 2015/12/16 00:00 [accepted] PHST- 2016/05/17 06:00 [entrez] PHST- 2016/05/18 06:00 [pubmed] PHST- 2017/02/18 06:00 [medline] PHST- 2016/07/01 00:00 [pmc-release] AID - JDI12462 [pii] AID - 10.1111/jdi.12462 [doi] PST - ppublish SO - J Diabetes Investig. 2016 Jul;7(4):514-21. doi: 10.1111/jdi.12462. Epub 2016 May 3.