PMID- 27181540
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20181202
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 55
IP  - 10
DP  - 2016
TI  - Light Chain Deposition Disease in an Older Adult Patient Successfully Treated 
      with Long-term Administration of Bortezomib, Melphalan and Prednisone.
PG  - 1319-25
LID - 10.2169/internalmedicine.55.5752 [doi]
AB  - A 70-year-old woman was admitted to our hospital because of fatigue and renal 
      dysfunction and was diagnosed with light chain deposition disease (LCDD) with 
      multiple organ involvement (kidney, thyroid gland, heart and eyes). After 
      chemotherapy with bortezomib, cyclophosphamide and dexamethasone, hepatobiliary 
      enzyme levels increased abruptly. A liver biopsy showed light chain deposition in 
      Disse spaces. After two years of treatment with bortezomib, melphalan and 
      prednisone (VMP) administered at shorter intervals relative to regular cycles, 
      the patient showed a hematological and organ response. This case indicates that a 
      relatively low dose intensity VMP regimen is preferable for elderly patients with 
      LCDD with multiple organ involvement.
FAU - Hiyamuta, Hiroto
AU  - Hiyamuta H
AD  - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, 
      Kyushu University, Japan.
FAU - Yamada, Shunsuke
AU  - Yamada S
FAU - Matsukuma, Yuta
AU  - Matsukuma Y
FAU - Tsuchimoto, Akihiro
AU  - Tsuchimoto A
FAU - Nakano, Toshiaki
AU  - Nakano T
FAU - Taniguchi, Masatomo
AU  - Taniguchi M
FAU - Masutani, Kosuke
AU  - Masutani K
FAU - Yoshimoto, Goichi
AU  - Yoshimoto G
FAU - Muta, Tsuyoshi
AU  - Muta T
FAU - Akashi, Koichi
AU  - Akashi K
FAU - Kitazono, Takanari
AU  - Kitazono T
FAU - Tsuruya, Kazuhiko
AU  - Tsuruya K
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160515
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 69G8BD63PP (Bortezomib)
RN  - Q41OR9510P (Melphalan)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & 
      dosage/*therapeutic use
MH  - Bortezomib/administration & dosage
MH  - Female
MH  - Humans
MH  - Liver Function Tests
MH  - Melphalan/administration & dosage
MH  - Paraproteinemias/*drug therapy
MH  - Prednisone/administration & dosage
MH  - Treatment Outcome
EDAT- 2016/05/18 06:00
MHDA- 2017/03/30 06:00
CRDT- 2016/05/17 06:00
PHST- 2016/05/17 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
AID - 10.2169/internalmedicine.55.5752 [doi]
PST - ppublish
SO  - Intern Med. 2016;55(10):1319-25. doi: 10.2169/internalmedicine.55.5752. Epub 2016 
      May 15.