PMID- 27182269
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160516
LR  - 20200930
IS  - 1682-024X (Print)
IS  - 1681-715X (Electronic)
IS  - 1681-715X (Linking)
VI  - 32
IP  - 2
DP  - 2016 Mar-Apr
TI  - Seroprevalence of acute dengue in a Malaysian tertiary medical centre.
PG  - 495-8
LID - 10.12669/pjms.322.9320 [doi]
AB  - OBJECTIVES: The aims of this study were to determine the seroprevalence of acute 
      dengue in Universiti Kebangsaan Malaysia (UKM) Medical Centre and its correlation 
      with selected haematological and biochemical parameters. METHODS: This 
      cross-sectional study was conducted from January to June 2015. A patient was 
      serologically diagnosed with acute dengue if the dengue virus IgG, IgM or NS-1 
      antigen was reactive. RESULTS: Out of 1,774 patients suspected to have acute 
      dengue, 1,153 were serologically diagnosed with the infection, resulting in a 
      seroprevalence of 64.9%. Dengue-positive patients had a lower mean platelet count 
      (89 x 10(9)/L) compared to the dengue-negative patients (171 x 10(9)/L) 
      (p<0.0001). The mean total white cell count was also lower in the dengue-positive 
      cases (4.7 x 10(9)/L vs. 7.2 x 10(9)/L; p<0.0001). The mean haematocrit was 
      higher in patients with acute dengue (42.5% vs. 40.0%; p<0.0001). Likewise, the 
      serum alanine transaminase level was also higher in patients with acute dengue 
      (108 U/L vs. 54 U/L; p<0.0001). CONCLUSIONS: Dengue is very prevalent in UKM 
      Medical Centre as most patients suspected to have acute dengue had serological 
      evidence of the infection. The platelet count was the single most likely 
      parameter to be abnormal (i.e. low) in patients with acute dengue.
FAU - Ding, Chuan Hun
AU  - Ding CH
AD  - Chuan Hun Ding, Department of Medical Microbiology & Immunology, Universiti 
      Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
FAU - Rashid, Zetti Zainol
AU  - Rashid ZZ
AD  - Zetti Zainol Rashid, Department of Medical Microbiology & Immunology, Universiti 
      Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
FAU - Rahman, Md Mostafizur
AU  - Rahman MM
AD  - Md. Mostafizur Rahman, Department of Medical Microbiology & Immunology, 
      Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
FAU - Khang, NanFeng
AU  - Khang N
AD  - NanFeng Khang, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 
      Malaysia.
FAU - Low, Wan Ngor
AU  - Low WN
AD  - Wan Ngor Low, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 
      Malaysia.
FAU - Hussin, Nurabrar
AU  - Hussin N
AD  - Nurabrar Hussin, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala 
      Lumpur, Malaysia.
FAU - Marzuki, Melissa Iqlima
AU  - Marzuki MI
AD  - Melissa Iqlima Marzuki, Faculty of Medicine, Universiti Kebangsaan Malaysia, 
      Kuala Lumpur, Malaysia.
FAU - Jaafar, Alyaa Nadhira
AU  - Jaafar AN
AD  - Alyaa Nadhira Jaafar, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala 
      Lumpur, Malaysia.
FAU - Roslan, Nurul Ain' Nabilla
AU  - Roslan NA
AD  - Nurul Ain' Nabilla Roslan, Faculty of Medicine, Universiti Kebangsaan Malaysia, 
      Kuala Lumpur, Malaysia.
FAU - Chandrasekaran, Terukumar
AU  - Chandrasekaran T
AD  - Terukumar Chandrasekaran, Faculty of Medicine, Universiti Kebangsaan Malaysia, 
      Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Med Sci
JT  - Pakistan journal of medical sciences
JID - 100913117
PMC - PMC4859052
OTO - NOTNLM
OT  - DENV
OT  - Dengue
OT  - IgG
OT  - IgM
OT  - NS1
OT  - Seroprevalence
EDAT- 2016/05/18 06:00
MHDA- 2016/05/18 06:01
PMCR- 2016/03/01
CRDT- 2016/05/17 06:00
PHST- 2016/05/17 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2016/05/18 06:01 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - PJMS-32-495 [pii]
AID - 10.12669/pjms.322.9320 [doi]
PST - ppublish
SO  - Pak J Med Sci. 2016 Mar-Apr;32(2):495-8. doi: 10.12669/pjms.322.9320.