PMID- 27183453
OWN - NLM
STAT- MEDLINE
DCOM- 20170613
LR  - 20220331
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 217
DP  - 2016 Aug 15
TI  - Quantitative comparison of 2D and 3D late gadolinium enhancement MR imaging in 
      patients with Fabry disease and hypertrophic cardiomyopathy.
PG  - 167-73
LID - S0167-5273(16)30873-7 [pii]
LID - 10.1016/j.ijcard.2016.04.175 [doi]
AB  - BACKGROUND: This study aims to determine whether the quantification of myocardial 
      fibrosis in patients with Fabry disease (FD) and hypertrophic cardiomyopathy 
      (HCM) using a late gadolinium enhancement (LGE) singlebreath-hold 
      three-dimensional (3D) inversion recovery magnetic resonance (MR) imaging 
      sequence is comparable with a clinically established two-dimensional (2D) 
      multi-breath-hold sequence. METHODS: In this retrospective, IRB-approved study, 
      40 consecutive patients (18 male; mean age 50+/-17years) with Fabry disease (n=18) 
      and HCM (n=22) underwent MR imaging at 1.5T. Spatial resolution was the same for 
      3D and 2D images (field-of-view, 350x350mm(2); in-plane-resolution, 1.2x1.2mm(2); 
      section-thickness, 8mm). Datasets were analyzed for subjective image quality; 
      myocardial and fibrotic mass, and total fibrotic tissue percentage were 
      quantified. RESULTS: There was no significant difference in subjective image 
      quality between 3D and 2D acquisitions (P=0.1 and P=0.3) for either disease. In 
      patients with Fabry disease there were no significant differences between 3D and 
      2D acquisitions for myocardial mass (P=0.55), fibrous tissue mass (P=0.89), and 
      total fibrous percentage (P=0.67), with good agreement between acquisitions 
      according to Bland-Altman analyses. In patients with HCM there were also no 
      significant differences between acquisitions for myocardial mass (P=0.48), 
      fibrous tissue mass (P=0.56), and total fibrous percentage (P=0.67), with good 
      agreement according to Bland-Altman analyses. Acquisition time was significantly 
      shorter for 3D (25+/-5s) as compared to the 2D sequence (349+/-62s, P<0.001). 
      CONCLUSIONS: In patients with Fabry disease and HCM, 3D LGE imaging provides 
      equivalent diagnostic information in regard to quantification of myocardial 
      fibrosis as compared with a standard 2D sequence, but at superior acquisition 
      speed.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Morsbach, F
AU  - Morsbach F
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland;
FAU - Gordic, S
AU  - Gordic S
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland;
FAU - Gruner, C
AU  - Gruner C
AD  - Cardiology Clinic, University Hospital Zurich, Zurich, Switzerland.
FAU - Niemann, M
AU  - Niemann M
AD  - Cardiology Clinic, University Hospital Zurich, Zurich, Switzerland; Institute for 
      Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.
FAU - Goetti, R
AU  - Goetti R
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland;
FAU - Gotschy, A
AU  - Gotschy A
AD  - Cardiology Clinic, University Hospital Zurich, Zurich, Switzerland; Institute for 
      Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; Division 
      of Internal Medicine, University Hospital Zurich, Zurich, Switzerland.
FAU - Kozerke, S
AU  - Kozerke S
AD  - Institute for Biomedical Engineering, University and ETH Zurich, Zurich, 
      Switzerland.
FAU - Alkadhi, H
AU  - Alkadhi H
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland;
FAU - Manka, R
AU  - Manka R
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, 
      Zurich, Switzerland;; Cardiology Clinic, University Hospital Zurich, Zurich, 
      Switzerland; Institute for Biomedical Engineering, University and ETH Zurich, 
      Zurich, Switzerland. Electronic address: robert.manka@usz.ch.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160503
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Int J Cardiol. 2018 Apr 1;256:35. PMID: 29395363
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging
MH  - Fabry Disease/*diagnostic imaging
MH  - Female
MH  - Gadolinium/*metabolism
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Young Adult
OTO - NOTNLM
OT  - Fabry disease
OT  - Hypertrophic cardiomyopathy
OT  - Late enhancement
OT  - Magnetic resonance imaging
OT  - Myocardium
EDAT- 2016/05/18 06:00
MHDA- 2017/06/14 06:00
CRDT- 2016/05/17 06:00
PHST- 2015/11/26 00:00 [received]
PHST- 2016/04/20 00:00 [revised]
PHST- 2016/04/30 00:00 [accepted]
PHST- 2016/05/17 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2017/06/14 06:00 [medline]
AID - S0167-5273(16)30873-7 [pii]
AID - 10.1016/j.ijcard.2016.04.175 [doi]
PST - ppublish
SO  - Int J Cardiol. 2016 Aug 15;217:167-73. doi: 10.1016/j.ijcard.2016.04.175. Epub 
      2016 May 3.