PMID- 2718377
OWN - NLM
STAT- MEDLINE
DCOM- 19890613
LR  - 20211203
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 170
IP  - 1
DP  - 1989 May
TI  - Host age and cell type influence measles virus protein expression in the central 
      nervous system.
PG  - 131-8
AB  - Measles virus infection of the central nervous system (CNS) of children can 
      result in a slow, progressive fatal disease, subacute sclerosing panencephalitis 
      (SSPE). The pathogenesis of persistent measles virus infection of the CNS has 
      been studied by comparing viral protein expression in suckling or weanling 
      hamsters infected with the HBS strain of measles virus. Suckling animals develop 
      a rapidly progressive fatal encephalitis while weanling animals survive and are 
      persistently infected. Viral nucleocapsid (NP) and hemagglutinin (H) proteins 
      have been examined during acute infection in suckling and weanling animals. Viral 
      H protein expression is selectively inhibited in infected neurons of weanling 
      animals, while infected ependymal cells retain the capability to express H 
      protein at the cell surface; suckling animals express high levels of both 
      proteins. Anti-measles antibodies are not responsible for the inhibition of H 
      protein since immunosuppression does not restore protein expression. The 
      cell-associated virus which is recovered late in infection by co-cultivation with 
      Vero cells expresses all viral proteins. These results suggest that intact viral 
      genome is present in persistent infections, and cell type or state of 
      differentiation of infected cells may be instrumental in expression of viral 
      proteins which can influence lytic or persistent outcome of infection.
FAU - Swoveland, P T
AU  - Swoveland PT
AD  - Department of Neurology, University of Maryland School of Medicine, Baltimore 
      21201.
FAU - Johnson, K P
AU  - Johnson KP
LA  - eng
GR  - NS20022/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Hemagglutinins, Viral)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nucleocapsid Proteins)
RN  - 0 (Nucleoproteins)
RN  - 0 (Viral Core Proteins)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Suckling/microbiology
MH  - Blotting, Western
MH  - Brain/*microbiology
MH  - Cricetinae
MH  - Gene Expression Regulation
MH  - Hemagglutinins, Viral/*genetics
MH  - Immunohistochemistry
MH  - Immunosuppression Therapy
MH  - Measles virus/*genetics/pathogenicity
MH  - Membrane Glycoproteins/genetics
MH  - Mesocricetus
MH  - Nucleocapsid Proteins
MH  - *Nucleoproteins
MH  - Vero Cells
MH  - Viral Core Proteins/*genetics
EDAT- 1989/05/01 00:00
MHDA- 1989/05/01 00:01
CRDT- 1989/05/01 00:00
PHST- 1989/05/01 00:00 [pubmed]
PHST- 1989/05/01 00:01 [medline]
PHST- 1989/05/01 00:00 [entrez]
AID - 10.1016/0042-6822(89)90360-7 [doi]
PST - ppublish
SO  - Virology. 1989 May;170(1):131-8. doi: 10.1016/0042-6822(89)90360-7.