PMID- 27186095
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160517
LR  - 20231111
IS  - 1179-1454 (Print)
IS  - 1179-1454 (Electronic)
IS  - 1179-1454 (Linking)
VI  - 2
DP  - 2010
TI  - The influence of dexamethasone and the role of some antioxidant vitamins in the 
      pathogenesis of experimental bronchial asthma.
PG  - 93-103
AB  - BACKGROUND: Bronchial asthma is a disease characterized by paroxysmal and 
      reversible obstruction of the airways. The imbalance between the oxidant and 
      antioxidant system that is called oxidative stress is critical in asthma 
      pathogenesis. It is likely, therefore, that antioxidants may be effective in the 
      treatment of asthma. Systemic treatment with glucocorticoids has been reported to 
      inhibit smooth muscle hypercontraction which may account partially for their 
      beneficial effects in the treatment of asthma. OBJECTIVE: The present study was 
      conducted in order to study the effect of dexamethasone and some antioxidant 
      vitamins on interleukin-4 (IL-4), immunoglobulin E (IgE) and heat shock protein 
      70 (Hsp70) in bronchial asthma in rats, and to recognize their possible 
      beneficial role. METHOD: The study was conducted on 60 adult male albino rats 
      randomly divided into 4 groups (15 for each group): including normal control 
      group (group A); asthma model group where rats were sensitized by ovalbumin and 
      challenged with antigen aerosol producing bronchial asthma (group B); asthma 
      model group treated with antioxidant vitamins (vitamin E and vitamin C) (group 
      C); asthma model group treated with dexamethasone (group D). Blood and lung 
      samples were collected from all groups. RESULTS AND CONCLUSION: Our results 
      revealed a significant decrease of serum reduced glutathione (GSH) levels among 
      groups B, C and D as compared to group A, while there was a significant increase 
      in group C and D as compared to group B. Antioxidant and dexamethasone treatment 
      resulted in a significant decrease of serum IL-4, malondialdehyde (MDA), and 
      serum IgE levels in group C and D as compared to group B. Antioxidant treatment 
      resulted in a significant decrease of serum Hsp70 level as compared to group B, 
      while dexamethasone treatment resulted in a significant increase of serum Hsp70 
      level as compared to group B. This study suggests that it is likely that a 
      combination of antioxidant vitamins may be effective in the treatment of asthma, 
      considering their reported effects on lowering MDA, IL-4, and IgE levels, and the 
      similar beneficial effects of dexamethasone in addition to increasing the 
      expression of Hsp70 in the studied model of bronchial asthma.
FAU - Nounou, H A
AU  - Nounou HA
AD  - Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Deif, M M
AU  - Deif MM
AD  - Physiology Department, College of Medicine, Alexandria University, Egypt.
FAU - Arafah, M
AU  - Arafah M
AD  - Pathology Department, College of Medicine, King Saud University, Riyadh, Saudi 
      Arabia.
LA  - eng
PT  - Journal Article
DEP - 20100720
PL  - New Zealand
TA  - J Exp Pharmacol
JT  - Journal of experimental pharmacology
JID - 101530345
PMC - PMC4863291
OTO - NOTNLM
OT  - heat shock protein 70
OT  - immunoglobulin E
OT  - interleukin-4
OT  - malondialdehyde
OT  - oxidative stresss
OT  - rats
OT  - reduced glutathione
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2010/07/20
CRDT- 2016/05/18 06:00
PHST- 2016/05/18 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2010/07/20 00:00 [pmc-release]
AID - jep-2-093 [pii]
AID - 10.2147/jep.s8313 [doi]
PST - epublish
SO  - J Exp Pharmacol. 2010 Jul 20;2:93-103. doi: 10.2147/jep.s8313. eCollection 2010.