PMID- 27186570
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160517
LR  - 20200930
IS  - 2288-6575 (Print)
IS  - 2288-6796 (Electronic)
IS  - 2288-6575 (Linking)
VI  - 90
IP  - 5
DP  - 2016 May
TI  - Risk factors for cancer recurrence or death within 6 months after liver resection 
      in patients with colorectal cancer liver metastasis.
PG  - 257-64
LID - 10.4174/astr.2016.90.5.257 [doi]
AB  - PURPOSE: The aim of this study was to find risk factors for early recurrence (ER) 
      and early death (ED) after liver resection for colorectal cancer liver metastasis 
      (CRCLM). METHODS: Between May 1990 and December 2011, 279 patients underwent 
      liver resection for CRCLM at Korea University Medical Center. They were assigned 
      to group ER (recurrence within 6 months after liver resection) or group NER 
      (non-ER; no recurrence within 6 months after liver resection) and group ED (death 
      within 6 months after liver resection) or group NED (alive > 6 months after liver 
      resection). RESULTS: The ER group included 30 patients (10.8%) and the NER group 
      included 247 patients (89.2%). The ED group included 18 patients (6.6%) and the 
      NED group included 253 patients (93.4%). Prognostic factors for ER in a 
      univariate analysis were poorly differentiated colorectal cancer (CRC), 
      synchronous metastasis, >/=5 cm of liver mass, >/=50 ng/mL preoperative 
      carcinoembryonic antigen level, positive liver resection margin, and surgery 
      alone without perioperative chemotherapy. Prognostic factors for ED in a 
      univariate analysis were poorly differentiated CRC, positive liver resection 
      margin, and surgery alone without perioperative chemotherapy. Multivariate 
      analysis showed that poorly differentiated CRC, >/=5-cm metastatic tumor size, 
      positive liver resection margin, and surgery alone without perioperative 
      chemotherapy were independent risk factors related to ER. For ED, poorly 
      differentiated CRC, positive liver resection margin, and surgery alone without 
      perioperative chemotherapy were risk factors in multivariate analysis. 
      CONCLUSION: Complete liver resection with clear resection margin and 
      perioperative chemotherapy should be carefully considered when patients have the 
      following preoperative risk factors: metastatic tumor size >/= 5 cm and poorly 
      differentiated CRC.
FAU - Jung, Sung Won
AU  - Jung SW
AD  - Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea 
      University College of Medicine, Seoul, Korea.
FAU - Kim, Dong-Sik
AU  - Kim DS
AD  - Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea 
      University College of Medicine, Seoul, Korea.
FAU - Yu, Young Dong
AU  - Yu YD
AD  - Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea 
      University College of Medicine, Seoul, Korea.
FAU - Han, Jae Hyun
AU  - Han JH
AD  - Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea 
      University College of Medicine, Seoul, Korea.
FAU - Suh, Sung-Ock
AU  - Suh SO
AD  - Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea 
      University College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160502
PL  - Korea (South)
TA  - Ann Surg Treat Res
JT  - Annals of surgical treatment and research
JID - 101622895
PMC - PMC4865703
OTO - NOTNLM
OT  - Chemotherapy
OT  - Disease-free survival
OT  - Liver metastasis
OT  - Resection
OT  - Survival analysis
COIS- CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2016/05/18 06:00
MHDA- 2016/05/18 06:01
PMCR- 2016/05/01
CRDT- 2016/05/18 06:00
PHST- 2015/12/16 00:00 [received]
PHST- 2016/02/07 00:00 [revised]
PHST- 2016/03/02 00:00 [accepted]
PHST- 2016/05/18 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2016/05/18 06:01 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - 10.4174/astr.2016.90.5.257 [doi]
PST - ppublish
SO  - Ann Surg Treat Res. 2016 May;90(5):257-64. doi: 10.4174/astr.2016.90.5.257. Epub 
      2016 May 2.