PMID- 27187042
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20180831
IS  - 1827-1715 (Electronic)
IS  - 0026-4946 (Linking)
VI  - 70
IP  - 2
DP  - 2018 Apr
TI  - IgE anti-Haemophilus influenzae type b (Hib) antibodies detected in serum of 
      Hib-vaccinated asthmatic and non-asthmatic pediatric patients.
PG  - 111-116
LID - 10.23736/S0026-4946.16.04564-3 [doi]
AB  - BACKGROUND: Haemophilus influenzae type b (Hib) bacterium causes severe illness 
      in infants and children, but has largely been eliminated by introducing a 
      universal Hib conjugate vaccine. While effects of certain vaccinations on atopic 
      disease have been studied, little is known about the relationship between Hib 
      vaccination and diseases of altered immunoglobulin E (IgE) regulation (asthma or 
      atopy). As such, it is necessary to provide more evidence concerning Hib 
      vaccination as a possible risk factor for atopic disease. METHODS: Total serum 
      IgE and IgE-and IgG-anti-Hib antibody responses were studied in Hib vaccinated 
      asthmatic (N.=14) and non-asthmatic children (N=26) (VaccZyme Human Anti Hib 
      Enzyme Immunoassay Kit). Data are reported as mean optical density (OD) values. 
      RESULTS: We found that: 1) total serum IgE levels were higher in asthmatic 
      compared with non-asthmatic subjects (389+/-125 vs. 125+/-129, P<0.001); 2) IgE and 
      IgG anti-Hib antibody responses were similar in both asthmatic and non-asthmatic 
      subjects (0.722+/-0.279 and 0.681+/-0.280, respectively; P=0.65; 0.450+/-0.505 and 
      0.573+/-0.779, respectively; P=0.580). CONCLUSIONS: The universal Hib vaccine 
      antigen did not result in either increased IgE, or IgG anti-Hib antibody 
      responses in asthmatic or non-asthmatics subjects. Thus, in this cohort, no 
      association between Hib vaccination and asthma status was identified.
FAU - Smith-Norowitz, Tamar A
AU  - Smith-Norowitz TA
AD  - Department of Pediatrics, Division of Infectious Diseases, State University of 
      New York Downstate Medical Center, Brooklyn, NY, USA - 
      tamar.smith-norowitz@downstate.edu.
FAU - Saadia, Tehila A
AU  - Saadia TA
AD  - Department of Pediatrics, Division of Infectious Diseases, State University of 
      New York Downstate Medical Center, Brooklyn, NY, USA.
FAU - Banniettis, Natalie
AU  - Banniettis N
AD  - Department of Pediatrics, Division of Infectious Diseases, State University of 
      New York Downstate Medical Center, Brooklyn, NY, USA.
FAU - Norowitz, Yitzchok M
AU  - Norowitz YM
AD  - Department of Pediatrics, Division of Infectious Diseases, State University of 
      New York Downstate Medical Center, Brooklyn, NY, USA.
FAU - Joks, Rauno
AU  - Joks R
AD  - Department of Medicine, Division of Allergy and Immunology, State University of 
      New York Downstate Medical Center, Brooklyn, NY, USA.
FAU - Hammerschlag, Margaret R
AU  - Hammerschlag MR
AD  - Department of Pediatrics, Division of Infectious Diseases, State University of 
      New York Downstate Medical Center, Brooklyn, NY, USA.
FAU - Durkin, Helen G
AU  - Durkin HG
AD  - Department of Pathology, State University of New York Downstate Medical Center, 
      Brooklyn, NY, USA.
FAU - Kohlhoff, Stephan
AU  - Kohlhoff S
AD  - Department of Pediatrics, Division of Infectious Diseases, State University of 
      New York Downstate Medical Center, Brooklyn, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20160517
PL  - Italy
TA  - Minerva Pediatr
JT  - Minerva pediatrica
JID - 0400740
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Haemophilus Vaccines)
RN  - 0 (Haemophilus influenzae type b polysaccharide vaccine)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Bacterial/*blood
MH  - Asthma/*immunology
MH  - Bacterial Capsules/immunology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Haemophilus Infections/prevention & control
MH  - Haemophilus Vaccines/*administration & dosage/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/blood
MH  - Infant
MH  - Male
MH  - Vaccination
MH  - Young Adult
EDAT- 2016/05/18 06:00
MHDA- 2018/09/01 06:00
CRDT- 2016/05/18 06:00
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2016/05/18 06:00 [entrez]
AID - R15Y9999N00A16051701 [pii]
AID - 10.23736/S0026-4946.16.04564-3 [doi]
PST - ppublish
SO  - Minerva Pediatr. 2018 Apr;70(2):111-116. doi: 10.23736/S0026-4946.16.04564-3. 
      Epub 2016 May 17.