PMID- 27187186
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20170816
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 145
DP  - 2016 Sep 1
TI  - A bioengineered drug-Eluting scaffold accelerated cutaneous wound healing In 
      diabetic mice.
PG  - 226-231
LID - S0927-7765(16)30325-3 [pii]
LID - 10.1016/j.colsurfb.2016.04.056 [doi]
AB  - Hyperglycemia in diabetic patients can greatly hinder the wound healing process. 
      In this study we investigated if the engagement of F4/80(+) murine macrophages 
      could accelerate the cutaneous wound healing in streptozotocin induced diabetic 
      mice. To facilitate the engagement of macrophages, we engineered a drug-eluting 
      electrospun scaffold with a payload of monocyte chemoattractant protein-1 
      (MCP-1). MCP-1 could be readily released from the scaffold within 3 days. The 
      electrospun scaffold showed no cytotoxic effects on human keratinocytes in vitro. 
      Full-thickness excisional cutaneous wound was created in diabetic mice. The wound 
      fully recovered within 10 days in mice treated with the drug-eluting scaffold. In 
      contrast, the wound took 14 days to fully recover in control groups. The use of 
      drug-eluting scaffold also improved the re-epithelialization. Furthermore, we 
      observed a larger population of F4/80(+) macrophages in the wound bed of mice 
      treated with drug-eluting scaffolds on day 3. This marked increase of macrophages 
      in the wound bed could have contributed to the accelerated wound healing. Our 
      study shed new light on an immuno-engineering solution for wound healing 
      management in diabetic patients.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Yin, Hao
AU  - Yin H
AD  - Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China; 
      Department of Surgery, The University of Chicago, Chicago, IL 60637, United 
      States.
FAU - Ding, Guoshan
AU  - Ding G
AD  - Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China.
FAU - Shi, Xiaoming
AU  - Shi X
AD  - Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China.
FAU - Guo, Wenyuan
AU  - Guo W
AD  - Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China.
FAU - Ni, Zhijia
AU  - Ni Z
AD  - Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China.
FAU - Fu, Hong
AU  - Fu H
AD  - Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China.
FAU - Fu, Zhiren
AU  - Fu Z
AD  - Organ Transplant Center, Shanghai Changzheng Hospital, Shanghai 200003, China. 
      Electronic address: zhirenfu.sh@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160503
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Bioengineering/*methods
MH  - Cattle
MH  - Chemokine CCL2/pharmacology
MH  - Diabetes Mellitus, Experimental/*pathology
MH  - Female
MH  - Immunohistochemistry
MH  - Macrophages/drug effects/metabolism
MH  - Mice, Inbred C57BL
MH  - Skin/drug effects/pathology
MH  - Tissue Scaffolds/*chemistry
MH  - *Wound Healing/drug effects
OTO - NOTNLM
OT  - Diabetic wound healing
OT  - Electrospinning
OT  - Monocyte chemoattractant protein-1
OT  - Tissue engineering
EDAT- 2016/05/18 06:00
MHDA- 2017/02/18 06:00
CRDT- 2016/05/18 06:00
PHST- 2016/02/03 00:00 [received]
PHST- 2016/04/29 00:00 [revised]
PHST- 2016/04/30 00:00 [accepted]
PHST- 2016/05/18 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
AID - S0927-7765(16)30325-3 [pii]
AID - 10.1016/j.colsurfb.2016.04.056 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2016 Sep 1;145:226-231. doi: 
      10.1016/j.colsurfb.2016.04.056. Epub 2016 May 3.