PMID- 27187457
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20181113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 8
IP  - 5
DP  - 2016 May 12
TI  - Effects of Low-Fat Diets Differing in Protein and Carbohydrate Content on 
      Cardiometabolic Risk Factors during Weight Loss and Weight Maintenance in Obese 
      Adults with Type 2 Diabetes.
LID - 10.3390/nu8050289 [doi]
LID - 289
AB  - Despite evidence for the benefits of higher-protein (HP) diets in weight loss, 
      their role in type 2 diabetes mellitus (T2DM) management and weight maintenance 
      is not clear. This randomised study compared the effects of a HP diet (38% 
      carbohydrate, 30% protein, 29% fat) to a isocaloric higher-carbohydrate diet (HC: 
      53%:21%:23%) on cardiometabolic risk factors for 12 weeks in energy restriction 
      (~30% reduction) followed by 12 weeks of energy balance whilst performing regular 
      exercise. Outcomes were measured at baseline and the end of each phase. Sixty-one 
      overweight/obese adults (BMI (body mass index) 34.3 +/- 5.1 kg/m(2), aged 55 +/- 8 
      years) with T2DM who commenced the study were included in the intention-to-treat 
      analysis including the 17 participants (HP n = 9, HC n = 8) who withdrew. 
      Following weight loss (M +/- SEM: -7.8 +/- 0.6 kg), there were significant reductions 
      in HbA1c (-1.4% +/- 0.1%, p < 0.001) and several cardiometabolic health risk 
      factors. Improvements were sustained for 12 weeks when weight was stabilised and 
      weight loss maintained. Both the HP and HC dietary patterns with concurrent 
      exercise may be effective strategies for weight loss and weight maintenance in 
      T2DM although further studies are needed to determine the longer term effects of 
      weight maintenance.
FAU - Watson, Nerylee
AU  - Watson N
AD  - Alliance for Research in Exercise, Nutrition and Activity, Sansom Institute for 
      Health Research, University of South Australia, GPO Box 2471, Adelaide 5001, SA, 
      Australia. nerylee.watson@mymail.unisa.edu.au.
FAU - Dyer, Kathryn
AU  - Dyer K
AD  - Alliance for Research in Exercise, Nutrition and Activity, Sansom Institute for 
      Health Research, University of South Australia, GPO Box 2471, Adelaide 5001, SA, 
      Australia. Kate.Dyer@unisa.edu.au.
FAU - Buckley, Jonathan
AU  - Buckley J
AD  - Alliance for Research in Exercise, Nutrition and Activity, Sansom Institute for 
      Health Research, University of South Australia, GPO Box 2471, Adelaide 5001, SA, 
      Australia. Jon.Buckley@unisa.edu.au.
FAU - Brinkworth, Grant
AU  - Brinkworth G
AD  - Food and Nutrition, Commonwealth Scientific and Industrial Research Organization, 
      PO Box 10041, Adelaide 5000, SA, Australia. grant.brinkworth@csiro.au.
FAU - Coates, Alison
AU  - Coates A
AD  - Alliance for Research in Exercise, Nutrition and Activity, Sansom Institute for 
      Health Research, University of South Australia, GPO Box 2471, Adelaide 5001, SA, 
      Australia. Alison.Coates@unisa.edu.au.
FAU - Parfitt, Gaynor
AU  - Parfitt G
AD  - Alliance for Research in Exercise, Nutrition and Activity, Sansom Institute for 
      Health Research, University of South Australia, GPO Box 2471, Adelaide 5001, SA, 
      Australia. Gaynor.Parfitt@unisa.edu.au.
FAU - Howe, Peter
AU  - Howe P
AD  - Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, 
      University of Newcastle, University Drive, Callaghan 2308, NSW, Australia. 
      Peter.Howe@newcastle.edu.au.
FAU - Noakes, Manny
AU  - Noakes M
AD  - Food and Nutrition, Commonwealth Scientific and Industrial Research Organization, 
      PO Box 10041, Adelaide 5000, SA, Australia. manny.noakes@csiro.au.
FAU - Murphy, Karen
AU  - Murphy K
AD  - Alliance for Research in Exercise, Nutrition and Activity, Sansom Institute for 
      Health Research, University of South Australia, GPO Box 2471, Adelaide 5001, SA, 
      Australia. Karen.Murphy@unisa.edu.au.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20160512
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
SB  - IM
EIN - Nutrients. 2017 Nov 24;9(12 ):null. PMID: 29186772
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiovascular Diseases/*blood
MH  - Diabetes Mellitus, Type 2/*diet therapy
MH  - *Diet, Fat-Restricted
MH  - Dietary Carbohydrates/*administration & dosage/analysis
MH  - Dietary Proteins/*administration & dosage/analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*diet therapy
MH  - Weight Loss
MH  - Young Adult
PMC - PMC4882702
OTO - NOTNLM
OT  - cardiovascular disease risk
OT  - glycaemic
OT  - obesity
OT  - type 2 diabetes
OT  - weight loss
OT  - weight maintenance
EDAT- 2016/05/18 06:00
MHDA- 2017/03/07 06:00
PMCR- 2016/05/01
CRDT- 2016/05/18 06:00
PHST- 2016/02/10 00:00 [received]
PHST- 2016/04/26 00:00 [revised]
PHST- 2016/05/05 00:00 [accepted]
PHST- 2016/05/18 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - nu8050289 [pii]
AID - nutrients-08-00289 [pii]
AID - 10.3390/nu8050289 [doi]
PST - epublish
SO  - Nutrients. 2016 May 12;8(5):289. doi: 10.3390/nu8050289.