PMID- 27189485
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20181113
IS  - 1476-7120 (Electronic)
IS  - 1476-7120 (Linking)
VI  - 14
IP  - 1
DP  - 2016 May 17
TI  - Long-term clinical and echocardiographic outcomes of extensive septal myectomy 
      for hypertrophic obstructive cardiomyopathy in Chinese patients.
PG  - 18
LID - 10.1186/s12947-016-0060-9 [doi]
LID - 18
AB  - BACKGROUND: There has been limited data addressing outcomes of extensive septal 
      myectomy in Chinese patients with hypertrophic obstructive cardiomyopathy (HOCM). 
      In this study, the objective was to evaluate the clinical and echocardiographic 
      outcomes of extensive septal myectomy in a relative large number of Chinese HOCM 
      patients over long-term follow-up. METHODS: We retrospectively studied 139 
      consecutive HOCM patients (age 43 +/- 15 years, 37 % male) who underwent extensive 
      left ventricular septal myectomy. During the perioperative period, all patients 
      were examined by echocardiography. All-cause death and cardiac death were 
      considered as primary endpoints during follow-up. Perioperative data was obtained 
      by retrospective review of institutional surgical databases. Follow-up data of 
      echocardiography and clinical status was recorded through outpatient interview. 
      RESULTS: Perioperative events consisted of arrhythmia, retraction injury to 
      aortic valve leaflets, pleural effusion, and hemodialysis and the use of 
      intra-aortic balloon pump. There was no in-hospital mortality. The follow-up 
      period averaged 5.6 +/- 0.9 years and overall survivals were 100.0, 99.3, 99.3, 
      98.5 and 97.8 % at 1, 2, 3, 4 and 5 years, respectively. Left ventricular outflow 
      tract (LVOT) gradient decreased form preoperative 84 +/- 17 mmHg to 12 +/- 3 mmHg at 
      2.5 years after surgery and it further reduced to 6 +/- 3 mmHg at 5 years after 
      surgery (P < 0.05). Compared with the preoperative levels, interventricualr 
      septal thickness decreased by 32 % while diastole left ventricular inner diameter 
      approximately increased by 10 % and ejection fraction (EF) was significantly 
      elevated during follow-up (P < 0.05). By echocardiography detection, mitral 
      regurgitation was ameliorated for HOCM patients after surgery. There was 
      significant improvement in New York Heart Association (NYHA) class. The 
      proportion of NYHA III and IV decreased from preoperative 58 to 19 % at 2.5 years 
      after surgery and it reduced to 11 % at 5 years after operation. CONCLUSION: 
      Extensive septal myectomy offers minimal operative risk and provides long-term 
      relief for LVOT obstruction in Chinese HOCM patients.
FAU - Yao, Lei
AU  - Yao L
AD  - Second Division of Ultrasound Diagnosis, Cangzhou Central Hospital, 16 
      Xin-Hua-West Street, Cangzhou, Hebei, 061001, People's Republic of China. 
      yaolei_pubmed@sina.com.
FAU - Li, Li
AU  - Li L
AD  - Second Division of Ultrasound Diagnosis, Cangzhou Central Hospital, 16 
      Xin-Hua-West Street, Cangzhou, Hebei, 061001, People's Republic of China.
FAU - Lu, Xiong-Jun
AU  - Lu XJ
AD  - Cardiothoracic Surgical Department, Shandong Chinese Medical Hospital, Jinan, 
      250011, China.
FAU - Miao, Yan-Ling
AU  - Miao YL
AD  - Second Division of Ultrasound Diagnosis, Cangzhou Central Hospital, 16 
      Xin-Hua-West Street, Cangzhou, Hebei, 061001, People's Republic of China.
FAU - Kang, Xiao-Ning
AU  - Kang XN
AD  - Second Division of Ultrasound Diagnosis, Cangzhou Central Hospital, 16 
      Xin-Hua-West Street, Cangzhou, Hebei, 061001, People's Republic of China.
FAU - Duan, Fu-Jian
AU  - Duan FJ
AD  - Ultrasonic Imaging Center, Fuwai Hospital, Chinese Academy of Medical Sciences, 
      Beijing, 100037, China.
LA  - eng
PT  - Journal Article
DEP - 20160517
PL  - England
TA  - Cardiovasc Ultrasound
JT  - Cardiovascular ultrasound
JID - 101159952
SB  - IM
MH  - Adult
MH  - Cardiac Surgical Procedures/*methods
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/physiopathology/surgery
MH  - China/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Septum/diagnostic imaging/*surgery
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Postoperative Complications/*epidemiology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC4869192
OTO - NOTNLM
OT  - Extensive septal myectomy
OT  - Hypertrophic cardiomyopathy
OT  - Hypertrophic obstructive cardiomyopathy
EDAT- 2016/05/18 06:00
MHDA- 2017/03/16 06:00
PMCR- 2016/05/17
CRDT- 2016/05/19 06:00
PHST- 2016/02/20 00:00 [received]
PHST- 2016/05/10 00:00 [accepted]
PHST- 2016/05/19 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/05/17 00:00 [pmc-release]
AID - 10.1186/s12947-016-0060-9 [pii]
AID - 60 [pii]
AID - 10.1186/s12947-016-0060-9 [doi]
PST - epublish
SO  - Cardiovasc Ultrasound. 2016 May 17;14(1):18. doi: 10.1186/s12947-016-0060-9.