PMID- 27189628
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20170217
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 77
IP  - 7
DP  - 2016 Jul
TI  - Distribution of HLA-DRB1 and HLA-DQB1 alleles in Lak population of Iran.
PG  - 580-3
LID - S0198-8859(16)30082-9 [pii]
LID - 10.1016/j.humimm.2016.05.011 [doi]
AB  - Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human 
      genome and encode the highly polymorphic molecules critically involved in immune 
      responses. Anthropological studies based on highly polymorphic HLA genes provide 
      useful information for bone marrow donor registry, forensic medicine, disease 
      association studies, as well as designing peptide vaccines against tumors, and 
      infectious or autoimmune diseases. The aim of this study was to determine the 
      HLA-DRB1 and HLA-DQB1 allele frequencies in 100 unrelated Lak individuals from 
      Lorestan province of Iran. Finally, we compared the results with those previously 
      described in four other Iranian populations. Commercial HLA-Type kits were used 
      for determination of the HLA-DRB1 and HLA-DQB1 allele frequencies. Differences 
      between populations in the distribution of HLA-DRB1 and HLA-DQB1 alleles were 
      estimated by chi2 test with Yate's correction and Fisher's exact test. The most 
      frequent HLA-DRB1 alleles were (*)1103=4 (23%), (*)1502 (9.5%), (*)0701 (9%), 
      (*)0301 (8.5%), (*)1101 (7.5%) and (*)1501 (6%) while HLA-DQB1(*)0301 (40%), 
      (*)0201 (15%), (*)0502 (10.5%), (*)0303 (10%), (*)0602=3 (9.5%), and (*)0501 
      (7.5%) were the most frequent alleles in Lak population. HLA-DRB1(*)0409, 
      (*)0804, (*)1102, (*)1112, (*)1405, and HLA-DQB1(*)0503, (*)0604 were the least 
      observed frequencies in Lak population. Our results based on HLA-DRB1 and 
      HLA-DQB1 allele frequencies showed that the Lak population possesses the 
      previously reported general features of the Lur and Kurd populations but still 
      with unique, decreased or increased frequencies of several alleles. In other 
      words, the Lak population is close to Lurs Khorramabadi and Kurd but far from 
      Lurs Kohkiloyeh/Boyerahmad and Bakhtiari.
CI  - Copyright (c) 2016 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Varzi, Ali Mohammad
AU  - Varzi AM
AD  - Department of Immunology, School of Medicine, Lorestan University of Medical 
      Sciences, Khorramabad, Iran. Electronic address: avarzi@yahoo.co.uk.
FAU - Shahsavar, Farhad
AU  - Shahsavar F
AD  - Department of Immunology, School of Medicine, Lorestan University of Medical 
      Sciences, Khorramabad, Iran. Electronic address: shahsavarfarhad@yahoo.com.
FAU - Tarrahi, Mohammad Javad
AU  - Tarrahi MJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Lorestan 
      University of Medical Sciences, Khorramabad, Iran. Electronic address: 
      tarrahi_mj@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20160514
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - Genetics, Population
MH  - Genotype
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Iran
MH  - Male
MH  - Polymorphism, Genetic
MH  - *Population Groups
MH  - Young Adult
OTO - NOTNLM
OT  - HLA class II
OT  - Iran
OT  - Lak population
OT  - PCR-SSP
EDAT- 2016/05/18 06:00
MHDA- 2017/02/18 06:00
CRDT- 2016/05/19 06:00
PHST- 2015/10/21 00:00 [received]
PHST- 2016/04/17 00:00 [revised]
PHST- 2016/05/13 00:00 [accepted]
PHST- 2016/05/19 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
AID - S0198-8859(16)30082-9 [pii]
AID - 10.1016/j.humimm.2016.05.011 [doi]
PST - ppublish
SO  - Hum Immunol. 2016 Jul;77(7):580-3. doi: 10.1016/j.humimm.2016.05.011. Epub 2016 
      May 14.