PMID- 27190787
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160518
LR  - 20200930
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 10
IP  - 4
DP  - 2016 Apr
TI  - Association Between Serum B12 and Serum Homocysteine Levels in Diabetic Patients 
      on Metformin.
PG  - BC01-4
LID - 10.7860/JCDR/2016/17604.7518 [doi]
AB  - INTRODUCTION: Type-2 Diabetes Mellitus (T2DM) and metformin both can lower serum 
      B12 (s.B12). Raised serum Homocysteine (s.Hcy) is considered as an early marker 
      of B12 deficiency. AIM: The study aimed to check whether homocysteine levels are 
      more sensitive indicator of s. B12 deficiency or not among diabetics using 
      metformin. MATERIALS AND METHODS: Mean s.B12 and s.Hcy levels of 30 cases 
      (diabetics on metformin <5years) were compared with 30 diabetic controls not on 
      metformin and 31 nondiabetic controls and statistically analysed by ANOVA and 
      post-hoc tests. RESULTS: No significant differences in either s.B12 mean or s.Hcy 
      mean were found between cases and diabetic controls. s.B12 mean did not differ 
      significantly but s.Hcy mean was significantly higher among nondiabetics as 
      compared to diabetic control. s. B12 level of Nondiabetic group was in borderline 
      category while mean s. B12 levels of cases and diabetic control groups was in 
      normal category but nearer to the lower cut off. Mean s.Hcy values in all the 
      groups were high. Pearson correlation showed strong association between s.B12 and 
      s.Hcy in all the groups. Additionally equation based on linear regression was 
      derived to calculate either of the s.B12 or s.Hcy. On Receiver Operative 
      Characteristic (ROC) curve, area under curve value was 0.842 for the value of 
      s.Hcy. CONCLUSION: In this study neither metformin nor T2DM could be identified 
      as a cause for s.B12 lowering and raised s.Hcy in the scenario of low normal 
      levels of s.B12 (<300pmol/L). If B12 deficiency recognized early using s. Hcy, 
      consequences due to B12 deficiency can be prevented or delayed among nondiabetics 
      as well as among diabetics and metformin users.
FAU - Upadhyay, Twinkal R
AU  - Upadhyay TR
AD  - Resident, Department of Biochemistry, H.M. Patel Centre for Medical Care and 
      Education, Pamukh Swami Medical College and Shree Krishna Hospital , Karamsad, 
      Gujarat, India .
FAU - Kothari, Nitin
AU  - Kothari N
AD  - Assistant Professor, Department of Pharmacology, Pacific Medical College and 
      Hospital , Udaipur, Rajasthan, India .
FAU - Shah, Hitesh
AU  - Shah H
AD  - Professor, Department of Biochemistry, H.M. Patel Centre for Medical Care and 
      Education, Pamukh Swami Medical College and Shree Krishna Hospital , Karamsad, 
      Gujarat, India .
LA  - eng
PT  - Journal Article
DEP - 20160401
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC4866085
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Malabsorption
OT  - Serum B12 deficiency
EDAT- 2016/05/18 06:00
MHDA- 2016/05/18 06:01
PMCR- 2016/04/01
CRDT- 2016/05/19 06:00
PHST- 2015/11/05 00:00 [received]
PHST- 2016/01/08 00:00 [accepted]
PHST- 2016/05/19 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2016/05/18 06:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2016/17604.7518 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2016 Apr;10(4):BC01-4. doi: 10.7860/JCDR/2016/17604.7518. Epub 
      2016 Apr 1.