PMID- 27190850
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160518
LR  - 20220120
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 10
IP  - 4
DP  - 2016 Apr
TI  - Correlation of Retinal Nerve Fiber Layer Thickness and Axial Length on Fourier 
      Domain Optical Coherence Tomography.
PG  - NC15-NC17
LID - 10.7860/JCDR/2016/15038.7672 [doi]
AB  - INTRODUCTION: The assessment of the peripapillary Retinal Nerve Fiber Layer 
      (RNFL) thickness has been an important tool for evaluating and diagnosing 
      glaucoma and its progression. Literature suggests that myopic eyes are at an 
      increased risk for developing glaucoma. This study gives an insight into the 
      relationship of RNFL thickness to the axial length in normal population. AIM: To 
      correlate the RNFL thickness and the axial length in normal individuals with 
      Fourier domain Optical Coherence Tomography (OCT). MATERIALS AND METHODS: In the 
      current study, 298 eyes of 149 normal individuals (10 years or older) with or 
      without refractive error were recruited. The RNFL thickness was measured using 
      Optovue (RTVue) three-dimensional Fourier domain OCT. RESULTS: We observed an 
      inverse relationship between average RNFL thickness and increasing axial 
      length(p=0.003). Maximum RNFL thickness was seen in the Infero-Temporal (IT) 
      quadrant and minimum in the Supero-Nasal (SN) quadrant. RNFL thickness did not 
      show any tendency to decline with age using the Pearsons correlation (r=0.07). 
      Females had an increased RNFL thickness in the Supero-Temporal (ST) and 
      Infero-Nasal (IN) quadrant (p-value 0.046 and 0.02) in comparison to males. There 
      was a statistically significant thinning in Ganglion Cell Complex (GCC) with 
      increasing axial length (p-value 0.000). CONCLUSION: The current study suggests 
      that the average RNFL thickness does not decrease with age. The RNFL and GCC 
      thickness shows an inverse correlation with axial length of the eyeball hence 
      observations have to be carefully interpreted in myopic eyes. Clinicians need to 
      keep the anatomical variations in RNFL for better patient management.
FAU - Dhami, Abhinav
AU  - Dhami A
AD  - Vitreoretina Fellow at Sankara Nethralaya Chennai, India.
FAU - Dhasmana, Renu
AU  - Dhasmana R
AD  - Associate Professor, Department of ophthalmology, Himalayan Institute of Medical 
      Sciences, Dehradun, India.
FAU - Nagpal, R C
AU  - Nagpal RC
AD  - Professor Emiratus, Department of Ophthalmology, Himalayan Institute of Medical 
      Sciences, Dehradun, India.
LA  - eng
PT  - Journal Article
DEP - 20160401
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC4866148
OTO - NOTNLM
OT  - Best corrected visual acuity
OT  - Ganglion cell complex
OT  - Goldmann's applanation tonometer
EDAT- 2016/05/18 06:00
MHDA- 2016/05/18 06:01
PMCR- 2016/04/01
CRDT- 2016/05/19 06:00
PHST- 2016/01/09 00:00 [received]
PHST- 2016/02/22 00:00 [accepted]
PHST- 2016/05/19 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2016/05/18 06:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2016/15038.7672 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2016 Apr;10(4):NC15-NC17. doi: 10.7860/JCDR/2016/15038.7672. 
      Epub 2016 Apr 1.