PMID- 27190887
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160518
LR  - 20200930
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 10
IP  - 4
DP  - 2016 Apr
TI  - Treatment of Resistant Cyclophosphamide Induced Haemorrhagic Cystitis: Review of 
      Literature and Three Case Reports.
PG  - PD15-6
LID - 10.7860/JCDR/2016/16948.7642 [doi]
AB  - Haemorrhagic Cystitis (HC) is defined as diffuse inflammatory bladder bleeding 
      due to many aetiologies. Massive HC often arises from anticancer chemotherapy or 
      radiotherapy for the treatment of pelvic malignancies. Phosphamides are the 
      anti-cancer drugs used for treating breast cancer, B-cell lymphoma, leukemia, 
      rheumatoid arthritis and systemic lupus erythaematosis by cross-linking strands 
      of DNA and preventing the cell division. They are also used in bone marrow 
      transplantation for prevention of Graft Versus Host Disease (GVHD). Hepatic 
      metabolism of phosphamide forms acrolein, and acrolein makes ulceration, 
      haemorrhage, edema and necrosis of the urothelium during its excretion by the 
      urine. Infectious causes of HC in immunocomprimesed patients are adenovirus, BK 
      polyoma-virus (BK), JC virus, and Cytomegalovirus (CMV). The present article 
      attempts to make a review of literature for the treatment of intractable HC and 
      report three cases with HC.
FAU - Ebiloglu, Turgay
AU  - Ebiloglu T
AD  - Faculty, Department of Urology, Etimesgut Military Hospital , Ankara, Turkey .
FAU - Kaya, Engin
AU  - Kaya E
AD  - Faculty, Department of Urology, Section of Pediatric Urology, Gulhane Military 
      Medical Academy , Ankara, Turkey .
FAU - Yilmaz, Sercan
AU  - Yilmaz S
AD  - Faculty, Department of Urology, Section of Pediatric Urology, Gulhane Military 
      Medical Academy , Ankara, Turkey .
FAU - Ozgur, Gokhan
AU  - Ozgur G
AD  - Faculty, Department of Heamatology, Gulhane Military Medical Academy , Ankara, 
      Turkey .
FAU - Kibar, Yusuf
AU  - Kibar Y
AD  - Faculty, Department of Urology, Section of Pediatric Urology, Gulhane Military 
      Medical Academy , Ankara, Turkey .
LA  - eng
PT  - Case Reports
DEP - 20160401
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC4866185
OTO - NOTNLM
OT  - Cidofoxin therapy
OT  - Clot
OT  - Haematuria
EDAT- 2016/05/18 06:00
MHDA- 2016/05/18 06:01
PMCR- 2016/04/01
CRDT- 2016/05/19 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2015/11/30 00:00 [accepted]
PHST- 2016/05/19 06:00 [entrez]
PHST- 2016/05/18 06:00 [pubmed]
PHST- 2016/05/18 06:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2016/16948.7642 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2016 Apr;10(4):PD15-6. doi: 10.7860/JCDR/2016/16948.7642. Epub 
      2016 Apr 1.