PMID- 27191791
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20181202
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 30
IP  - 9
DP  - 2016 Sep
TI  - Brain-derived Neurotrophic Factor Signaling Mediates the Antidepressant-like 
      Effect of the Total Flavonoids of Alpiniae Oxyphyllae Fructus in Chronic 
      Unpredictable Mild Stress Mice.
PG  - 1493-502
LID - 10.1002/ptr.5651 [doi]
AB  - The present study verified the antidepressant-like effects of the total 
      flavonoids of Alpinia oxyphylla Miq. (AOF) using the chronic unpredictable mild 
      stresses paradigm and explored the mechanism that underlies antidepressant-like 
      effects of AOF in mice. Previous research has shown that tropomyosin-related 
      kinase B (TrkB) receptor-mediated extracellular regulated protein kinases (ERK) 
      signaling pathways participate in depression pathophysiology. Therefore, we aimed 
      to explore whether AOF improved depression-like behaviors by increasing activity 
      of ERK pathways mediated by TrkB. Results showed that AOF significantly reduced 
      the immobility time in the forced swimming test and increased the sucrose 
      preference in sucrose preference test. In addition, decreased phosphorylated 
      cyclic adenosine monophosphate response element-binding protein (pCREB)/CREB, 
      pERK/ERK, and pTrkB/TrkB levels in the hippocampus induced by chronic 
      unpredictable mild stresses were reversed by intragastric administration of AOF. 
      Results suggested that AOF increased pCREB/CREB, pERK/ERK, and pTrkB/TrkB levels 
      by acting on the TrkB receptor. To verify this hypothesis, mice were pretreated 
      with the TrkB inhibitor K252a (or 0.1% dimethyl sulfoxide, intraperitoneally, 
      2 weeks), before the intragastric administration of AOF. This resulted in an 
      absence of antidepressant-like effects, as well as no activation of 
      pERK/pCREB/BDNF signaling pathways. Results demonstrated that AOF might exert 
      antidepressant-like effects by targeting TrkB receptor-mediated pERK/pCREB/BDNF 
      signal systems, which could help to identify the AOF receptor. Copyright (c) 2016 
      John Wiley & Sons, Ltd.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Yan, Tingxu
AU  - Yan T
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, China.
FAU - Wu, Bo
AU  - Wu B
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, China.
FAU - Liao, Zheng-Zheng
AU  - Liao ZZ
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, China.
FAU - Liu, Bing
AU  - Liu B
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, China.
FAU - Zhao, Xu
AU  - Zhao X
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, China.
FAU - Bi, Kai-Shun
AU  - Bi KS
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, 
      Shenyang, China.
FAU - Jia, Ying
AU  - Jia Y
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, China.
LA  - eng
PT  - Journal Article
DEP - 20160518
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonoids)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Alpinia/*chemistry
MH  - Animals
MH  - Antidepressive Agents/pharmacology/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Flavonoids/*pharmacology
MH  - Male
MH  - Mice
MH  - Signal Transduction
MH  - Stress, Psychological
OTO - NOTNLM
OT  - Alpinia oxyphylla Miq
OT  - K252a
OT  - brain-derived neurotrophic factor (BDNF)
OT  - chronic unpredictable mild stress (CUMS)
OT  - depression
OT  - total flavonoids
EDAT- 2016/05/19 06:00
MHDA- 2017/04/25 06:00
CRDT- 2016/05/19 06:00
PHST- 2015/07/10 00:00 [received]
PHST- 2016/03/31 00:00 [revised]
PHST- 2016/04/30 00:00 [accepted]
PHST- 2016/05/19 06:00 [entrez]
PHST- 2016/05/19 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
AID - 10.1002/ptr.5651 [doi]
PST - ppublish
SO  - Phytother Res. 2016 Sep;30(9):1493-502. doi: 10.1002/ptr.5651. Epub 2016 May 18.