PMID- 27192948
OWN - NLM
STAT- MEDLINE
DCOM- 20170126
LR  - 20170126
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 94
IP  - 8
DP  - 2016 Dec
TI  - Choroidal thickness does not predict visual acuity in young high myopes.
PG  - e709-e715
LID - 10.1111/aos.13084 [doi]
AB  - PURPOSE: To investigate the influence of choroidal thickness (CT) on visual 
      acuity (VA) in young persons with extremely high myopia. METHODS: We conducted a 
      case-control study of young men with extremely high myopia and controls with 
      emmetropia recruited from a mandatory medical eye review for employment purposes. 
      Retinal and choroidal imaging was performed using enhanced depth imaging (EDI) 
      spectral-domain optical coherence tomography (SD-OCT). RESULTS: We included 105 
      extremely high myopic subjects with spherical equivalent (SE) -10 dioptre (D) or 
      worse and 50 emmetropic subjects with SE less than 0.5 D. The mean SE was 
      -11.56 +/- 2.04 D (range, -10 to -23 D) for myopic group and 0.14 +/- 0.25 D for 
      emmetropic group. The mean age of included myopic and emmetropic subjects was 
      21.51 +/- 1.22 years and 21.96 +/- 0.89 years, respectively. In the univariate 
      analysis, subfoveal CT was significantly associated with best-corrected visual 
      acuity (BCVA) (beta = -0.039, p = 0.015). However, in the multiple linear regression 
      analysis, after adjusting for SE and presence of any pathological myopia lesions 
      such as posterior staphyloma, lacquer cracks or chorioretinal atrophy, subfoveal 
      CT was not independently associated with BCVA (p = 0.937). CONCLUSION: Extremely 
      high myopic eyes had thinner choroid, but CT was not an independent predictor of 
      VA. Other factors related to myopia are likely responsible for the diminished VA 
      in young extremely high myopic eyes.
CI  - (c) 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Gupta, Preeti
AU  - Gupta P
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore, Singapore.
FAU - Cheung, Carol Y
AU  - Cheung CY
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore, Singapore.
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore, Singapore.
FAU - Saw, Seang-Mei
AU  - Saw SM
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore, Singapore.
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore, Singapore.
FAU - Koh, Victor
AU  - Koh V
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore, Singapore.
FAU - Tan, Mellisa
AU  - Tan M
AD  - DSO National Laboratories, Defence Medical and Environmental Research Institute, 
      Singapore, Singapore.
FAU - Yang, Adeline
AU  - Yang A
AD  - DSO National Laboratories, Defence Medical and Environmental Research Institute, 
      Singapore, Singapore.
FAU - Zhao, Paul
AU  - Zhao P
AD  - Vision Performance Centre, Military Medical Institute, Singapore Armed Forces, 
      Singapore, Singapore.
FAU - Cheung, Chui Ming Gemmy
AU  - Cheung CM
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
FAU - Wong, Tien Yin
AU  - Wong TY
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore, Singapore.
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
FAU - Cheng, Ching-Yu
AU  - Cheng CY
AD  - Singapore Eye Research Institute and Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore and National University Health System, Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20160519
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Choroid/diagnostic imaging/*pathology
MH  - Emmetropia
MH  - Humans
MH  - Male
MH  - Myopia, Degenerative/*diagnosis/physiopathology
MH  - Organ Size
MH  - Retina/diagnostic imaging/pathology
MH  - Tomography, Optical Coherence
MH  - Vision Disorders/*diagnosis/physiopathology
MH  - *Visual Acuity
MH  - Young Adult
OTO - NOTNLM
OT  - choroidal thickness
OT  - enhanced depth imaging optical coherence tomography
OT  - high myopes
OT  - visual acuity
EDAT- 2016/05/20 06:00
MHDA- 2017/01/27 06:00
CRDT- 2016/05/20 06:00
PHST- 2015/06/26 00:00 [received]
PHST- 2016/03/07 00:00 [accepted]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2017/01/27 06:00 [medline]
PHST- 2016/05/20 06:00 [entrez]
AID - 10.1111/aos.13084 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2016 Dec;94(8):e709-e715. doi: 10.1111/aos.13084. Epub 2016 May 
      19.