PMID- 27192959
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20220330
IS  - 1521-6551 (Electronic)
IS  - 1521-6543 (Linking)
VI  - 68
IP  - 7
DP  - 2016 Jul
TI  - Association of NOS2 and NOS3 gene polymorphisms with susceptibility to type 2 
      diabetes mellitus and diabetic nephropathy in the Chinese Han population.
PG  - 516-25
LID - 10.1002/iub.1513 [doi]
AB  - Inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase 
      (NOS3) gene play important roles in the susceptibility to type 2 diabetes 
      mellitus (T2DM). The present study aims to detect the potential association of 
      NOS2 and NOS3 gene polymorphisms with the susceptibility toT2DM and diabetic 
      nephropathy (DN) in the Chinese Han population. Four hundred and ninety T2DM 
      patients and 485 healthy controls were enrolled in this case-control study. The 
      genotypes of NOS2 and NOS3 gene polymorphisms were analyzed by the polymerase 
      chain reaction (PCR)-ligase detection reaction (LDR) method. Our data 
      demonstrated that the NOS2 rs2779248 and NOS2 rs1137933 genetic polymorphisms 
      were significantly associated with the increased susceptibility to T2DM in the 
      heterozygote comparison, dominant model, and allele contrast; and NOS3 rs3918188 
      genetic polymorphism was significantly associated with the increased 
      susceptibility to T2DM in the homozygote comparison and recessive model. The 
      allele-C and genotype-TC of NOS2 rs2779248, allele-A and genotype-GA of NOS2 
      rs1137933 and genotype-AA of NOS3 rs3918188 genetic polymorphisms might be the 
      risk factors for increasing the susceptibility to T2DM. And a significant 
      haplotype effect of NOS2 rs10459953/C- rs1137933/G- rs2779248/T was found between 
      T2DM cases and controls. Moreover, NOS3 rs1800783 polymorphism was significantly 
      associated with the increased susceptibility to DN in the heterozygote 
      comparison, recessive model and allele contrast. At last, a positive correlation 
      of family history of diabetes with NOS3 rs11771443 polymorphism was found in DN. 
      These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and 
      NOS3 rs3918188 genetic polymorphisms are potentially related to the 
      susceptibility to T2DM, and the rs1800783 polymorphism might be considered as 
      genetic risk factors for diabetic nephropathy, and family history of diabetes was 
      closely associated with rs11771443 polymorphism in DN, and the genetic variants 
      might be used as molecular markers for evaluating the risk of T2DM and diabetic 
      nephropathy. (c) 2016 IUBMB Life, 68(7):516-525, 2016.
CI  - (c) 2016 International Union of Biochemistry and Molecular Biology.
FAU - Chen, Feng
AU  - Chen F
AD  - Department of Toxicology, XiangYa School of Public Health, Central South 
      University, Changsha, Hunan, China.
AD  - Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and 
      Prevention, Shenzhen, Guangdong, China.
AD  - Department of Pharmacy, Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Li, Yu-Mei
AU  - Li YM
AD  - Department of Pharmacy, Xiangya Hospital of Central South University, Changsha, 
      Hunan, China.
FAU - Yang, Lin-Qing
AU  - Yang LQ
AD  - Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and 
      Prevention, Shenzhen, Guangdong, China.
FAU - Zhong, Cai-Gao
AU  - Zhong CG
AD  - Department of Toxicology, XiangYa School of Public Health, Central South 
      University, Changsha, Hunan, China.
FAU - Zhuang, Zhi-Xiong
AU  - Zhuang ZX
AD  - Department of Toxicology, XiangYa School of Public Health, Central South 
      University, Changsha, Hunan, China.
AD  - Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and 
      Prevention, Shenzhen, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20160518
PL  - England
TA  - IUBMB Life
JT  - IUBMB life
JID - 100888706
RN  - EC 1.14.13.39 (NOS2 protein, human)
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Diabetic Nephropathies/*genetics/pathology
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide Synthase Type II/*genetics
MH  - Nitric Oxide Synthase Type III/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - diabetic nephropathy
OT  - nitric oxide synthase
OT  - polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2016/05/20 06:00
MHDA- 2017/09/02 06:00
CRDT- 2016/05/20 06:00
PHST- 2016/02/04 00:00 [received]
PHST- 2016/04/20 00:00 [accepted]
PHST- 2016/05/20 06:00 [entrez]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
AID - 10.1002/iub.1513 [doi]
PST - ppublish
SO  - IUBMB Life. 2016 Jul;68(7):516-25. doi: 10.1002/iub.1513. Epub 2016 May 18.