PMID- 27193219
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20221207
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 61
IP  - 9
DP  - 2016 Sep
TI  - A significant association between rs8067378 at 17q12 and invasive cervical cancer 
      originally identified by a genome-wide association study in Han Chinese is 
      replicated in a Japanese population.
PG  - 793-6
LID - 10.1038/jhg.2016.50 [doi]
AB  - In this study, associations between invasive cervical cancer and four cervical 
      cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 
      and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a 
      Japanese population. Human leukocyte antigen (HLA)-DPB1 alleles were also 
      investigated for their association with cervical cancer risk in the Japanese 
      population. After receiving written informed consent, 214 unrelated Japanese 
      women with invasive cervical cancer and 288 cancer-free Japanese women were 
      recruited, and DNA samples were obtained (study protocol approved by 
      Institutional Review Board of Nagasaki University). Of the four single-nucleotide 
      polymorphisms, rs8067378 showed a significant association with invasive cervical 
      cancer (P=0.0071). Under a recessive model, the minor allele G of rs8067378 
      contributed to the risk of invasive cervical cancer (odds ratio=2.92, 95% 
      confidence interval=1.40-6.36; P=0.0021). No association was detected between 
      HLA-DPB1 alleles and cervical cancer risk in the Japanese population. In 
      conclusion, we show for the first time, to the best of our knowledge, that an 
      association between increased risk of invasive cervical cancer and rs8067378 in 
      the Han Chinese population is replicated in a Japanese population. In addition, 
      Japanese women with the GG genotype of rs8067378 are a candidate high-risk group 
      for invasive cervical carcinoma.
FAU - Miura, Kiyonori
AU  - Miura K
AUID- ORCID: 0000-0001-5396-8881
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Mishima, Hiroyuki
AU  - Mishima H
AUID- ORCID: 0000-0001-5050-2509
AD  - Department of Human Genetics, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Yasunami, Michio
AU  - Yasunami M
AD  - Department of Pediatric Infectious Disease, Institute of Tropical Medicine, 
      Nagasaki, Japan.
FAU - Kaneuchi, Masanori
AU  - Kaneuchi M
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Kitajima, Michio
AU  - Kitajima M
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Abe, Shuhei
AU  - Abe S
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Higashijima, Ai
AU  - Higashijima A
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Fuchi, Naoki
AU  - Fuchi N
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Miura, Shoko
AU  - Miura S
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Yoshiura, Koh-Ichiro
AU  - Yoshiura K
AD  - Department of Human Genetics, Nagasaki University Graduate School of Biomedical 
      Sciences, Nagasaki, Japan.
FAU - Masuzaki, Hideaki
AU  - Masuzaki H
AD  - Department of Obstetrics and Gynecology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160519
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - *Chromosomes, Human, Pair 17
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - Genotype
MH  - HLA-DP beta-Chains/genetics
MH  - Humans
MH  - Japan
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - *Quantitative Trait Loci
MH  - Risk
MH  - Uterine Cervical Neoplasms/*genetics/*pathology
EDAT- 2016/05/20 06:00
MHDA- 2017/04/07 06:00
CRDT- 2016/05/20 06:00
PHST- 2015/12/17 00:00 [received]
PHST- 2016/04/12 00:00 [revised]
PHST- 2016/04/13 00:00 [accepted]
PHST- 2016/05/20 06:00 [entrez]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
AID - jhg201650 [pii]
AID - 10.1038/jhg.2016.50 [doi]
PST - ppublish
SO  - J Hum Genet. 2016 Sep;61(9):793-6. doi: 10.1038/jhg.2016.50. Epub 2016 May 19.