PMID- 27193424
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0920-9069 (Print)
IS  - 1573-0778 (Electronic)
IS  - 0920-9069 (Linking)
VI  - 68
IP  - 6
DP  - 2016 Dec
TI  - Endogenous and tumour-derived microRNAs regulate cross-presentation in dendritic 
      cells and consequently cytotoxic T cell function.
PG  - 2223-2233
AB  - Dendritic cells (DCs) are potent antigen presenting cells (APCs). They are also 
      specialized in the induction of cytotoxic T lymphocyte mediated responses against 
      extracellular antigens, including tumour-specific antigens, by presenting 
      peptide-Major Histocompatibility Complex (MHC) I complexes to naive CD8(+) T 
      cells in lymphoid tissues, a process called cross-presentation. Emerging evidence 
      suggests that the efficiency of cross-presentation can be influenced by a unique 
      set of microRNAs (miRNAs). Some are differentially expressed in the course of 
      morphological and functional development of DCs while tumorigenic miRNAs 
      (onco-miRs) can be delivered to and inserted into DCs via exosomes. The latter 
      reprogram the miRNA repertoire of DCs, transforming them from effective APCs to 
      negative modulators of immunity, ultimately aiding cancers to evade host 
      immunity. On the other hand, endogenous microRNAs can influence 
      cross-presentation either positively or negatively. In this review, we discuss 
      the possible mechanisms by which specific miRNAs influence cross-presentation as 
      well as the viability of manipulating the expression of miRNAs that regulate DC 
      cross-presentation as a potential cancer immunotherapy intervention.
FAU - Kikete, Siambi
AU  - Kikete S
AD  - Tianjin University of Traditional Chinese Medicine, No. 88, Yuquan Road, NanKai 
      District, Tianjin, 300193, China.
FAU - Chu, Xiaoqian
AU  - Chu X
AD  - Tianjin University of Traditional Chinese Medicine, No. 88, Yuquan Road, NanKai 
      District, Tianjin, 300193, China.
FAU - Wang, Li
AU  - Wang L
AD  - Tianjin Second People's Hospital, Nankai District, Tianjin, 300192, China.
FAU - Bian, Yuhong
AU  - Bian Y
AD  - Tianjin University of Traditional Chinese Medicine, No. 88, Yuquan Road, NanKai 
      District, Tianjin, 300193, China. bianyuhong_2012@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160518
PL  - United States
TA  - Cytotechnology
JT  - Cytotechnology
JID - 8807027
PMC - PMC5101325
OTO - NOTNLM
OT  - Cross-presentation
OT  - Dendritic cell
OT  - Major histocompatibility complex
OT  - microRNA
EDAT- 2016/05/20 06:00
MHDA- 2016/05/20 06:01
PMCR- 2017/12/01
CRDT- 2016/05/20 06:00
PHST- 2015/12/18 00:00 [received]
PHST- 2016/04/20 00:00 [accepted]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2016/05/20 06:01 [medline]
PHST- 2016/05/20 06:00 [entrez]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 10.1007/s10616-016-9975-0 [pii]
AID - 9975 [pii]
AID - 10.1007/s10616-016-9975-0 [doi]
PST - ppublish
SO  - Cytotechnology. 2016 Dec;68(6):2223-2233. doi: 10.1007/s10616-016-9975-0. Epub 
      2016 May 18.