PMID- 27194244
OWN - NLM
STAT- MEDLINE
DCOM- 20171201
LR  - 20181202
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Print)
IS  - 1465-9921 (Linking)
VI  - 17
IP  - 1
DP  - 2016 May 18
TI  - Toxic and adjuvant effects of silica nanoparticles on ovalbumin-induced allergic 
      airway inflammation in mice.
PG  - 60
LID - 10.1186/s12931-016-0376-x [doi]
LID - 60
AB  - BACKGROUND: Silica nanoparticles (SNPs) can easily enter in respiratory system 
      via inhalation because of their low molecular weight and ease of dispersion. 
      Toxicity and adverse effects of SNPs vary according to the physical 
      characteristics of the particle. METHODS: To evaluate the toxic and adjuvant 
      effects of 3 types of SNPs in the airway system, six-week-old female BALB/c mice 
      were intranasally administered 3 types of SNPs (spherical [S-SNP], mesoporous 
      [M-SNP], and polyethylene glycol-conjugated [P-SNP]) alone or SNPs/ovalbumin 
      (OVA), three times weekly for 2 weeks. Airway hyper-responsiveness (AHR), 
      bronchoalveolar lavage fluid (BALF), cytokine levels, and histology of the lungs 
      were analyzed. RESULTS: The S-SNPs/OVA group and M-SNPs/OVA group showed 
      significant AHR, compared to the control group. Among all SNP-treated groups, the 
      group administered SNPs/OVA showed greater inflammatory cell infiltration in 
      BALF, extensive pathological changes, and higher cytokine levels (IL-5, IL-13, 
      IL-1beta, and IFN-gamma) than those administered SNPs alone or saline/OVA. CONCLUSION: 
      Exposure to SNPs alone and SNPs/OVA induced toxicity in the respiratory system. 
      SNPs alone showed significant toxic effects on the airway system. Meanwhile, 
      SNPs/OVA exerted adjuvant effects to OVA of inducing allergic airway 
      inflammation. In particular, M-SNPs showed the most severe airway inflammation in 
      both direct toxicity and adjuvant effect assays. P-SNPs induced less inflammation 
      than the other types of SNPs in both models.
FAU - Han, Heejae
AU  - Han H
AD  - Department of Internal Medicine, Institute of Allergy, Yonsei University College 
      of Medicine, Seoul, Republic of Korea.
FAU - Park, Yoon Hee
AU  - Park YH
AD  - Department of Internal Medicine, Institute of Allergy, Yonsei University College 
      of Medicine, Seoul, Republic of Korea.
FAU - Park, Hye Jung
AU  - Park HJ
AD  - Department of Internal Medicine, Institute of Allergy, Yonsei University College 
      of Medicine, Seoul, Republic of Korea.
AD  - Department of Internal Medicine, Division of Allergy and Immunology, Yonsei 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Kangtaek
AU  - Lee K
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      Republic of Korea.
FAU - Um, Kiju
AU  - Um K
AD  - Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 
      Republic of Korea.
FAU - Park, Jung-Won
AU  - Park JW
AD  - Department of Internal Medicine, Institute of Allergy, Yonsei University College 
      of Medicine, Seoul, Republic of Korea.
AD  - Department of Internal Medicine, Division of Allergy and Immunology, Yonsei 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Jae-Hyun
AU  - Lee JH
AD  - Department of Internal Medicine, Institute of Allergy, Yonsei University College 
      of Medicine, Seoul, Republic of Korea. jhleemd@yuhs.ac.
AD  - Department of Internal Medicine, Division of Allergy and Immunology, Yonsei 
      University College of Medicine, Seoul, Republic of Korea. jhleemd@yuhs.ac.
AD  - Department of Internal Medicine, Division of Allergy and Immunology, Institute of 
      Allergy, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 
      120-752, Seoul, Republic of Korea. jhleemd@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20160518
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Bronchial Hyperreactivity/chemically induced/physiopathology
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Bronchoconstriction/drug effects
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Inflammation Mediators/metabolism
MH  - Inhalation Exposure
MH  - Lung/*drug effects/immunology/metabolism/physiopathology
MH  - Mice, Inbred BALB C
MH  - Nanoparticles/chemistry/*toxicity
MH  - *Ovalbumin
MH  - Pneumonia/*chemically induced/immunology/metabolism/physiopathology
MH  - Polyethylene Glycols/toxicity
MH  - Porosity
MH  - Silicon Dioxide/chemistry/*toxicity
PMC - PMC4870782
OTO - NOTNLM
OT  - Adjuvant effect
OT  - Airway Inflammation
OT  - Nanoparticle
OT  - PEGylation
OT  - Silica
OT  - Toxicity
EDAT- 2016/05/20 06:00
MHDA- 2017/12/02 06:00
PMCR- 2016/05/18
CRDT- 2016/05/20 06:00
PHST- 2015/10/08 00:00 [received]
PHST- 2016/05/06 00:00 [accepted]
PHST- 2016/05/20 06:00 [entrez]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2017/12/02 06:00 [medline]
PHST- 2016/05/18 00:00 [pmc-release]
AID - 10.1186/s12931-016-0376-x [pii]
AID - 376 [pii]
AID - 10.1186/s12931-016-0376-x [doi]
PST - epublish
SO  - Respir Res. 2016 May 18;17(1):60. doi: 10.1186/s12931-016-0376-x.