PMID- 27194794
OWN - NLM
STAT- MEDLINE
DCOM- 20180118
LR  - 20181113
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 23
IP  - 6
DP  - 2016 Jun
TI  - Influence of pharmacological manipulations of NMDA and cholinergic receptors on 
      working versus reference memory in a dual component odor span task.
PG  - 270-7
LID - 10.1101/lm.041251.115 [doi]
AB  - Developed as a tool to assess working memory capacity in rodents, the odor span 
      task (OST) has significant potential to advance drug discovery in animal models 
      of psychiatric disorders. Prior investigations indicate OST performance is 
      impaired by systemic administration of N-methyl-d-aspartate receptor (NMDA-r) 
      antagonists and is sensitive to cholinergic manipulations. The present study 
      sought to determine whether an impairment in OST performance can be produced by 
      systemic administration of the competitive NMDA-r antagonist 
      3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP; 3, 10, 17 mg/kg i.p.) 
      in a unique dual-component variant of the OST, and whether this impairment is 
      ameliorated by nicotine (0.75 mg/kg i.p.). Male Sprague-Dawley rats were trained 
      to asymptotic level of performance on a 24-trial two-comparison incrementing 
      nonmatching to sample OST. In addition, rats were administered a two-comparison 
      olfactory reference memory (RM) task, which was integrated into the OST. The RM 
      task provided an assessment of the effects of drug administration on global 
      behavioral measures, long-term memory and motivation. Several measures of working 
      memory (span, longest run, and accuracy) were dose dependently impaired by CPP 
      without adversely affecting RM. Analysis of drug effects across trial blocks 
      demonstrated a significant impairment of performance even at low memory loads, 
      suggesting a CPP-induced deficit of olfactory short-term memory that is not 
      load-dependent. Although nicotine did not ameliorate CPP-induced impairments in 
      span or accuracy, it did block the impairment in longest run produced by the 10 
      mg/kg dose of CPP. Overall, our results indicate that performance in our 24 odor 
      two-comparison OST is capacity dependent and that CPP impaired OST working, but 
      not reference, memory.
CI  - (c) 2016 MacQueen et al.; Published by Cold Spring Harbor Laboratory Press.
FAU - MacQueen, David A
AU  - MacQueen DA
AD  - Moffitt Cancer Center, Tampa, Florida 33612, USA Department of Psychology, 
      University of South Florida, Tampa, Florida 33620, USA.
FAU - Dalrymple, Savannah R
AU  - Dalrymple SR
AD  - Medical Research Service, VA Hospital, Tampa, Florida 33612, USA Department of 
      Psychology, University of South Florida, Tampa, Florida 33620, USA.
FAU - Drobes, David J
AU  - Drobes DJ
AD  - Moffitt Cancer Center, Tampa, Florida 33612, USA Department of Psychology, 
      University of South Florida, Tampa, Florida 33620, USA Department of Oncologic 
      Sciences, University of South Florida, Tampa, Florida 33620, USA.
FAU - Diamond, David M
AU  - Diamond DM
AD  - Medical Research Service, VA Hospital, Tampa, Florida 33612, USA Department of 
      Psychology, University of South Florida, Tampa, Florida 33620, USA Department of 
      Molecular Pharmacology and Physiology, University of South Florida, Tampa, 
      Florida 33620, USA Center for Preclinical and Clinical Research on PTSD, 
      University of South Florida, Tampa, Florida 33620, USA ddiamond@mail.usf.edu.
LA  - eng
PT  - Journal Article
DEP - 20160518
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (Piperazines)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Receptors, Nicotinic)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 98Y1I8ZD4M (3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Excitatory Amino Acid Antagonists/administration & dosage
MH  - Male
MH  - Memory, Short-Term/*drug effects
MH  - Motivation/drug effects
MH  - Nicotine/*administration & dosage
MH  - Nicotinic Agonists/*administration & dosage
MH  - Odorants
MH  - Olfactory Perception/drug effects
MH  - Piperazines/*administration & dosage
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors/physiology
MH  - Receptors, Nicotinic
PMC - PMC4880146
EDAT- 2016/05/20 06:00
MHDA- 2018/01/19 06:00
PMCR- 2017/06/01
CRDT- 2016/05/20 06:00
PHST- 2015/12/01 00:00 [received]
PHST- 2016/03/13 00:00 [accepted]
PHST- 2016/05/20 06:00 [entrez]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2018/01/19 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 23/6/270 [pii]
AID - MacQueenLM041251 [pii]
AID - 10.1101/lm.041251.115 [doi]
PST - epublish
SO  - Learn Mem. 2016 May 18;23(6):270-7. doi: 10.1101/lm.041251.115. Print 2016 Jun.