PMID- 27195243
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160519
LR  - 20200930
IS  - 2235-8676 (Print)
IS  - 2235-8668 (Electronic)
IS  - 2235-8668 (Linking)
VI  - 3
IP  - 3-4
DP  - 2016 Apr
TI  - Association between Tumor Necrosis Factor-alpha (-238G/A and -308G/A) Gene 
      Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis.
PG  - 217-28
LID - 10.1159/000443770 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory pleiotropic cytokine which 
      may contribute to the initiation and progression of ischemic stroke (IS). Thus 
      far, numerous studies have been performed to examine the association between 
      -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms in the promoter regions 
      of the TNF-alpha gene and susceptibility to IS, but results are still conflicting. 
      The aim of this meta-analysis is to provide a relatively comprehensive account of 
      the association between TNF-alpha -238G/A and -308G/A gene polymorphisms and 
      susceptibility to IS. A literature search for eligible candidate gene studies 
      published before April 20, 2015, was conducted in the PubMed, Medline, EMBASE and 
      Google Scholar databases. The following combinations of main keywords were used: 
      ('Tumor Necrosis Factor-Alpha' or 'TNF-alpha') and ('ischemic stroke' or 'cerebral 
      infarction' or 'IS') and ('genetic polymorphism' or 'single nucleotide 
      polymorphisms' or 'SNP'). Fixed- or random-effect models were used to estimate 
      the pooled odds ratio (OR) and 95% confidence interval (CI). Meta-analysis was 
      carried out by using RevMan 5.3 software. For TNF-alpha -238G/A gene polymorphism, 7 
      case-control studies with a total of 1,846 IS patients and 1,905 controls showed 
      a significant association with susceptibility to IS under a dominant model (AA + 
      GA vs. GG; OR, 1.40; 95% CI, 1.11-1.76; p value 0.004). For TNF-alpha -308G/A gene 
      polymorphism, 16 case-control studies with a total of 5,651 IS patients and 5,792 
      controls showed a significant protective association with susceptibility to IS 
      under a dominant model (AA + GA vs. GG; OR, 0.78, 95% CI, 0.63-0.97; p value 
      0.03). Our meta-analysis shows that TNF-alpha -238G/A gene polymorphism is more 
      likely to be associated with the risk of IS in Caucasian populations as compared 
      to Asian populations. However, TNF-alpha -308G/A gene polymorphism is more likely to 
      be protective against IS in Asian populations as compared to Caucasian 
      populations. Further large, well-designed prospective epidemiological studies are 
      needed to confirm these findings.
FAU - Kumar, Pradeep
AU  - Kumar P
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Misra, Shubham
AU  - Misra S
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Kumar, Amit
AU  - Kumar A
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Pandit, Awadh Kishor
AU  - Pandit AK
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Chakravarty, Kamalesh
AU  - Chakravarty K
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Prasad, Kameshwar
AU  - Prasad K
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi, 
      India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160217
PL  - Switzerland
TA  - Pulse (Basel)
JT  - Pulse (Basel, Switzerland)
JID - 101644596
PMC - PMC4865080
OTO - NOTNLM
OT  - Cerebral infarction
OT  - Cytokines
OT  - Inflammatory gene
OT  - Ischemic stroke
OT  - Meta-analysis
OT  - Polymorphisms
OT  - Tumor necrosis factor-alpha
EDAT- 2016/05/20 06:00
MHDA- 2016/05/20 06:01
PMCR- 2016/02/17
CRDT- 2016/05/20 06:00
PHST- 2016/05/20 06:00 [entrez]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2016/05/20 06:01 [medline]
PHST- 2016/02/17 00:00 [pmc-release]
AID - pls-0003-0217 [pii]
AID - 10.1159/000443770 [doi]
PST - ppublish
SO  - Pulse (Basel). 2016 Apr;3(3-4):217-28. doi: 10.1159/000443770. Epub 2016 Feb 17.