PMID- 27195251
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160519
LR  - 20200930
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 5
DP  - 2016
TI  - Interaction of central Angiotensin II and estrogen on systolic blood pressure in 
      female DOCA-salt treated rats.
PG  - 78
LID - 10.4103/2277-9175.180990 [doi]
LID - 78
AB  - BACKGROUND: There is a probable interaction of central angiotensin II (Ang II) 
      and estrogen (Est) on blood pressure in deoxycorticosterone acetate (DOCA)-salt 
      hypertensive rats. Therefore, in the present study, the interaction between Ang 
      II and Est in ovariectomized (Ovx) and Sham rats that were treated with DOCA- 
      salt was evaluated. MATERIALS AND METHODS: The female rats were divided into 10 
      groups as follows: Sham, Ovx, Sham-DOCA, Ovx-DOCA, Sham-DOCA-estrogen (E), Ovx 
      DOCA-E, Sham-DOCA-losartan (L), Ovx-DOCA-L, Sham-DOCA-L-E, and Ovx-DOCA-L-E. The 
      Est groups received estradiol valerate (2 mg/kg; daily; subcutaneously (s.c)) for 
      four weeks. Following that, several doses of Ang II (0.5, 5, 50, 500, 5000 ng/5 
      mul) were injected via the intracerebroventricular (i.c.v) route and the changes 
      in systolic blood pressure (SBP) were evaluated. In the losartan groups, 200 mug 
      losartan was injected (i.c.v) 15 minutes after the Ang II injection and the blood 
      pressure was recorded. Treatment by DOCA was performed by removal of one kidney, 
      injection of DOCA (45 mg/kg i.p), and adding of sodium chloride (NaCl) (1%) and 
      potassium chloride (KCl) (0.1%) in the drinking water. RESULTS: The SBP was 
      increased by Ang II and this effect in DOCA-salt treated rat was higher than in 
      the untreated groups. The effect of Ang II on SBP in groups that were treated 
      with Est and L was lower than that in the DOCA-salt groups. Increase in SBP was 
      strongly attenuated by Ang II in groups that were co-treated with both Est and L 
      compared to the DOCA-treated rats. These results showed that Est significantly 
      attenuated the effect of central Ang II on SBP in the DOCA-salt treated rats. 
      CONCLUSION: We suggest that there are interactions between E and Ang II in the 
      control of blood pressure in DOCA-salt treated rats.
FAU - Kafami, Marzieh
AU  - Kafami M
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Hosseini, Mahmoud
AU  - Hosseini M
AD  - Neurocognetive Research Center, Faculty of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Niazmand, Saeed
AU  - Niazmand S
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Hadjzadeh, Mousa Alreza
AU  - Hadjzadeh MA
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran; Neurocognetive Research Center, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Farrokhi, Esmaeil
AU  - Farrokhi E
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Mazloum, Tahereh
AU  - Mazloum T
AD  - Neurocognetive Research Center, Faculty of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Shafei, Mohammad Naser
AU  - Shafei MN
AD  - Neurogenic Inflammation Research Center, School of Medicine, Mashhad University 
      of Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20160421
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC4863408
OTO - NOTNLM
OT  - Ang II
OT  - DOCA-salt
OT  - Ovx
OT  - blood pressure
OT  - estrogen
OT  - losartan
COIS- Conflict of Interest: None declared.
EDAT- 2016/05/20 06:00
MHDA- 2016/05/20 06:01
PMCR- 2016/04/21
CRDT- 2016/05/20 06:00
PHST- 2014/04/22 00:00 [received]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2016/05/20 06:00 [entrez]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2016/05/20 06:01 [medline]
PHST- 2016/04/21 00:00 [pmc-release]
AID - ABR-5-78 [pii]
AID - 10.4103/2277-9175.180990 [doi]
PST - epublish
SO  - Adv Biomed Res. 2016 Apr 21;5:78. doi: 10.4103/2277-9175.180990. eCollection 
      2016.