PMID- 27195741
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20181202
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 62
IP  - 4
DP  - 2016 Jul-Aug
TI  - Ramp Study Hemodynamics, Functional Capacity, and Outcome in Heart Failure 
      Patients with Continuous-Flow Left Ventricular Assist Devices.
PG  - 442-6
LID - 10.1097/MAT.0000000000000387 [doi]
AB  - Ramp studies-measuring changes in cardiac parameters as a function of serial pump 
      speed changes (revolutions per minute [rpm])-are increasingly used to evaluate 
      function and malfunction of continuous-flow left ventricular assist devices 
      (CF-LVADs). We hypothesized that ramp studies can predict functional capacity, 
      quality of life (QOL), and survival in CF-LVAD patients. Hemodynamic changes per 
      Deltarpm were measured at a minimum of CF-LVAD support, at baseline pump speed, and 
      at maximal tolerable pump speed. Subsequently functional capacity and QOL were 
      assessed. Eighty ramp tests were performed in 44 patients (HeartMate II, Thoratec 
      Corporation, Pleasanton, CA). Functional status was evaluated in 70% (31/44); 
      average 6 minute walk test (6MWT) was 312 +/- 220 min, New York Heart Association 
      (NYHA) I-II/III-IV (70/30%) and activity scores very low-low/moderate-very high 
      (55/45%). Decrease in pulmonary capillary wedge pressure per Deltarpm was related to 
      better NYHA classification; NYHA I-II vs. III-IV, -0.29 +/- 0.15 vs. 
      -0.09 +/- 0.16 mm Hg/rpm * 10 (p = 0.007) as well as to activity score; very 
      low-low vs. moderate-very high, -0.16 +/- 0.16 vs. -0.31 +/- 0.16 mm Hg/rpm * 10 (p = 
      0.02). Cardiac output change per Deltarpm was correlated to measures of QOL. Ramp 
      tests did not predict survival. In conclusion, hemodynamic changes during ramp 
      studies are associated with measures of functional capacity and QOL. Hence, such 
      tests could potentially identify patients in risk of failure to thrive during 
      CF-LVAD support.
FAU - Jung, Mette H
AU  - Jung MH
AD  - From the *Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; and 
      daggerDepartment of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland.
FAU - Gustafsson, Finn
AU  - Gustafsson F
FAU - Houston, Brian
AU  - Houston B
FAU - Russell, Stuart D
AU  - Russell SD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Adult
MH  - Cardiac Output/physiology
MH  - Female
MH  - Heart Failure/physiopathology/psychology/*therapy
MH  - *Heart-Assist Devices/adverse effects
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Wedge Pressure/physiology
MH  - Quality of Life
EDAT- 2016/05/20 06:00
MHDA- 2017/11/07 06:00
CRDT- 2016/05/20 06:00
PHST- 2016/05/20 06:00 [entrez]
PHST- 2016/05/20 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
AID - 10.1097/MAT.0000000000000387 [doi]
PST - ppublish
SO  - ASAIO J. 2016 Jul-Aug;62(4):442-6. doi: 10.1097/MAT.0000000000000387.